A CMOS-compatible optical biosensing system based on visible absorption spectroscopy

被引:0
|
作者
Chang, Yu-Wei [1 ]
Yu, Ping-Chun [2 ]
Huang, Yang-Tung [1 ]
Yang, Yuh-Shyong [2 ]
机构
[1] Natl Chiao Tung Univ, Dept Elect Engn, Hsinchu, Taiwan
[2] Natl Chiao Tung Univ, Dept Biological Sci & Technol, Hsinchu, Taiwan
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中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
A CMOS-compatible optical biosensing system based on visible absorption spectroscopy is proposed. Within the compact prototype, the CMOS sensor consisting a P+/N-well finger photodiode and a transimpedance amplifier (TIA) is implemented in a standard 0.35-mu m CMOS technology. The ABTS/H2O2/HRP method is adopted as the ground for medical diagnosis, Experimental results demonstrate that the minimum concentration successfully detected for H2O2 is 1 mu M. The detection limit is one order of magnitude better than a traditional CMOS biosensor, and comparable to a commercial spectrophotometer.
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页码:1099 / +
页数:2
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