Synthesis of DNA dumbbell based inhibitors for the human DNA methyltransferase Dnmt1

被引：12
|
作者：
Kuch, David [1 ]
Schermelleh, Lothar [2 ]
Manetto, Susanne [1 ]
Leonhardt, Heinrich [2 ]
Carell, Thomas [1 ]
机构：
[1] Univ Munich, Dept Chem & Biochem, Ctr Integrated Protein Sci, D-81377 Munich, Germany
[2] Univ Munich, Dept Biol 2, Ctr Integrated Protein Sci, D-82152 Martinsried, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 08期
关键词：
DNA methylation; enzymes; epigenetics; transferases;
D O I：
10.1002/anie.200702055
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) Dumbbells that block: Dnmt1 is a crucial enzyme in maintaining the methylation pattern of genes and as such is a critical element of the epigenetic programming process. DNA dumbbell constructs have been developed that inhibit Dnmt1 and have potential in the regulation of DNA methylation patterns in cells (see scheme; SAM=S-adenosylmethionine, Fl=Cy3 fluorescence label, CN=5-azadC, C-Me=5-methyldC). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：1515 / 1518
页数：4
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