Clonal distribution of multidrug-resistant Enterobacter cloacae

被引:31
|
作者
Girlich, Delphine [1 ]
Poirel, Laurent [1 ,2 ]
Nordmann, Patrice [1 ,2 ,3 ]
机构
[1] INSERM, Emerging Resistance Antibiot U914, K Bicetre, France
[2] Univ Fribourg, Fac Sci, Dept Med, Med & Mol Microbiol, CH-1700 Fribourg, Switzerland
[3] Hop Cantonal Fribourg, Hop Fribourgeois, Fribourg, Switzerland
关键词
Multidrug-resistant bacteria; Prevalence; MLST; Enterobacter cloacae; INTENSIVE-CARE-UNIT; BETA-LACTAMASE; OUTBREAK;
D O I
10.1016/j.diagmicrobio.2015.01.003
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
A multilocus sequence typing (MIST) scheme including 7 housekeeping genes was used to evaluate whether the current spread of multidrug-resistant Enterobacter cloacae isolates worldwide might be associated to specific successful clones. Fifty E. cloacae clinical isolates of worldwide origin, with various beta-lactamase content, and recovered at different periods of time were studied. Forty-four sequence types were identified, highlighting a high clonal diversity with 3 main lineages. This study revealed that a precise identification of the isolates by sequencing of the chromosomal ampC gene of E. cloacae would provide a significant added value to improve the reliability of the MLST scheme. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码:264 / 268
页数:5
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