Lessons from precision medicine in rheumatology

被引：7
|
作者：
Muskardin, Theresa L. Wampler [1 ]
Paredes, Jacqueline L. [1 ]
Appenzeller, Simone [2 ]
Niewold, Timothy B. [1 ]
机构：
[1] NYU, Sch Med, Colton Ctr Autoimmun, 435 E 30th St, New York, NY 10016 USA
[2] Univ Estadual Campinas, Sch Med Sci, Dept Med, Rheumatol Unit, Campinas, Brazil
来源：
MULTIPLE SCLEROSIS JOURNAL | 2020年 / 26卷 / 05期
基金：
巴西圣保罗研究基金会; 新加坡国家研究基金会;
关键词：
Beta-interferon; immunology; biomarkers; genetics; neuromyelitis optica; SYSTEMIC-LUPUS-ERYTHEMATOSUS; I INTERFERON; ARTHRITIS; MULTIPLE; NEPHRITIS; INHIBITION; SIGNATURE; ANTIBODY; FEATURES; GENES;
D O I：
10.1177/1352458519884249
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are two common autoimmune rheumatic diseases that vary in severity, clinical presentation, and disease course between individuals. Molecular and genetic studies of both diseases have identified candidate genes and molecular pathways that are linked to various disease outcomes and treatment responses. Currently, patients can be grouped into molecular subsets in each disease, and these molecular categories should enable precision medicine approaches to be applied in rheumatic diseases. In this article, we will review key lessons learned about disease heterogeneity and molecular characterization in rheumatology, which we hope will lead to personalized therapeutic strategies.
引用
收藏
页码：533 / 539
页数：7
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