The molecular relationships between apoptosis, autophagy and necroptosis

被引：138
|
作者：
Lalaoui, Najoua [1 ,2 ]
Lindqvist, Lisa M. [1 ,2 ]
Sandow, Jarrod J. [1 ,2 ]
Ekert, Paul G. [1 ,2 ,3 ,4 ]
机构：
[1] Walter & Eliza Hall Inst Med Res, Div Cell Signalling & Cell Death, Parkville, Vic 3050, Australia
[2] Univ Melbourne, Dept Med Biol, Parkville, Vic 3050, Australia
[3] Royal Childrens Hosp, Murdoch Childrens Res Inst, Parkville, Vic 3052, Australia
[4] Univ Melbourne, Royal Childrens Hosp, Dept Paediat, Parkville, Vic 3052, Australia
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2015年 / 39卷
基金：
澳大利亚国家健康与医学研究理事会;
关键词：
Caspases; Apoptosis; Autophagy; Necroptosis; RECEPTOR-INTERACTING PROTEIN; PROGRAMMED CELL-DEATH; MIXED LINEAGE KINASE; DOMAIN-LIKE PROTEIN; SIGNALING COMPLEX DISC; TUMOR-NECROSIS-FACTOR; BCL-2; FAMILY-MEMBERS; SERINE-PROTEASE; CYTOCHROME-C; TNF-ALPHA;
D O I：
10.1016/j.semcdb.2015.02.003
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Cells are constantly subjected to a vast range of potentially lethal insults, which may activate specific molecular pathways that have evolved to kill the cell. Cell death pathways are defined partly by their morphology, and more specifically by the molecules that regulate and enact them. As these pathways become more thoroughly characterized, interesting molecular links between them have emerged, some still controversial and others hinting at the physiological and pathophysiological roles these death pathways play. We describe specific molecular programs controlling cell death, with a focus on some of the distinct features of the pathways and the molecular links between them. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：63 / 69
页数：7
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