Mismatch Correction for Free-breathing PFT and Deep-inspiration Breath-holding CT in PET/CT Imaging

CT images acquired during deep-inspiration breath holding (DIBH) have higher image quality than free-breathing (FB) CT images as they are free from respiratory motion artifacts. However, there exists significant mismatch between DIBH CT images and FB PET images since the displacement of organs in the thorax and abdomen at DIBH is significantly larger than that during regular FB. Our goal is to correct for the large mismatch between FB PET and DIBH CT in PET/CT imaging. The list-mode PET data were divided into four equal-count frames using amplitude based data-driven respiratory gating technique. Frame 1 and Frame 4 corresponded to end-expiration and end-inspiration respectively, and they were reconstructed using OSEM image reconstruction algorithm. To avoid attenuation-activity mismatch artifacts, the attenuation map used in attenuation correction was modified by filling the lung region with attenuation coefficient of soft tissue. 3D motion vector field from Frame 4 to Frame 1 was calculated from the reconstructed PET images using B-spline image registration algorithm. Assuming the respiratory motion during FB is consistent during FB and DIBH, the motion vector field from DIBH to end-inspiration phase is modeled by scaling the calculated respiratory motion from Frame 4 to Frame 1. The scalar was determined by maximizing the mutual information between transformed DIBH attenuation map and PET image at Frame 4. DIBH attenuation map was transformed using the scaled motion vector field from Frame 4 to Frame 1 to obtain attenuation map at Frame 4. Attenuation maps for other frames were obtained by transforming attenuation map at Frame 4 using corresponding motion vector fields. The method was applied to clinical patient data acquired using DIBH CT and FB PET protocol. While DIBH attenuation map creates significant mismatch artifacts in PET images, the proposed method was able to generate attenuation maps matching FB PET frames and reduce mismatch artifacts.