NOV-002, a glutathione disulfide mimetic, is a pleiotropic modulator of cellular redox balance

被引：1
|
作者：
Tew, Kenneth D. [2 ]
He, Lin [1 ]
Hutchens, Steven [1 ]
VandenBerg, Tracy E. [1 ]
Pazoles, Christopher J. [3 ]
Townsend, Danyelle M. [1 ]
机构：
[1] Med Univ S Carolina, Dept Pharmaceut & Biomed Sci, Charleston, SC 29425 USA
[2] Med Univ S Carolina, Dept Cell & Mol Pharmacol & Expt Therapeut, Charleston, SC 29425 USA
[3] Novelos Therapeut Inc, Newton, MA USA
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2008年 / 62卷 / 07期
关键词：
D O I：
10.1016/j.biopha.2008.06.022
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
21
引用
收藏
页码：427 / 427
页数：1
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    Townsend, Danyelle M.
    [J]. BIOMEDICINE & PHARMACOTHERAPY, 2008, 62 (08) : 514 - 514
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  • [3] NOV-002, a mimetic of glutathione disulfide
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    [J]. EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2008, 17 (07) : 1075 - 1083
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    [J]. BIOMEDICINE & PHARMACOTHERAPY, 2009, 63 (02) : 75 - 78
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  • [6] In vivo pharmacokinetic and pharmacodynamic behavior of NOV-002, a redox-modulating glutathione disulfide mimetic
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    [J]. CANCER RESEARCH, 2009, 69
  • [7] Protective effects of a glutathione disulfide mimetic (NOV-002) against cisplatin induced kidney toxicity
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    [J]. BIOMEDICINE & PHARMACOTHERAPY, 2010, 64 (01) : 73 - 76
  • [8] The glutathione disulfide mimetic NOV-002 inhibits cyclophosphamide-induced hematopoietic and immune suppression by reducing oxidative stress
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    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2012, 52 (09) : 1560 - 1568
  • [9] NOV-002, a redox-modulating glutathione disulfide mimetic, leads to calcium influx and nitric oxide generation through eNOS activation in myeloid cells
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  • [10] Mechanism of action studies of NOV-002, a novel glutathione disulfide anticancer drug.
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    [J]. CLINICAL CANCER RESEARCH, 2005, 11 (24) : 9083S - 9083S
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