Second transplantation with CD34+ blood cells from an HLA-mismatched related donor after engraftment failure of transplanted cord blood cells

被引：0
|
作者：
Ohta, H [1 ]
Kim, JY [1 ]
Sawada, A [1 ]
Tokimasa, S [1 ]
Fujisaki, H [1 ]
Matsuda, Y [1 ]
Osugi, Y [1 ]
Hara, J [1 ]
机构：
[1] Osaka Univ, Grad Sch Med, Dept Dev Med Pediat, Suita, Osaka 5650871, Japan
来源：
INTERNATIONAL JOURNAL OF HEMATOLOGY | 2001年 / 74卷 / 03期
关键词：
second transplantation; CD34(+) blood cells; engraftment failure; cord blood transplantation;
D O I：
10.1007/BF02982071
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Unrelated cord blood transplantation (CBT) has been worldwide for bone marrow reconstitution. CBT is associated with a high frequency of engraftment failure and rejection due to a small dose of graft cells. In cases of engraftment failure or rejection following unrelated CBT retransplantation from the original donors is impossible. We report a successful transplantation with CD34(+) blood cells selected from a 2-loci HLA-mismatched mother to a child with acute monocytic leukemia after engraftment failure of the primary CBT. Selected CD34(+) blood cell transplantation is a useful approach for retransplantation in the setting of engraftment failure. (C) 2001 The Japanese Society of Hematology.
引用
收藏
页码：338 / 341
页数：4
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