Non-invasive opening of BBB by focused ultrasound

被引：0

作者：

Hynynen, K ^{[1
]}

McDannold, N ^{[1
]}

Vykhodtseva, N ^{[1
]}

Jolesz, FA ^{[1
]}

机构：

[1] Brigham & Womens Hosp, Dept Radiol, Boston, MA 02115 USA

来源：

BRAIN EDEMA XII | 2003年 / 86卷

关键词：

blood brain barrier; brain; ultrasound; drug delivery; therapy;

D O I：

暂无

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Blood brain barrier (BBB) is a major barrier for delivering therapeutic agents in the brain. In this study we investigated the feasibility of open the BBB by using focused ultrasound. Rabbit brains were exposed to pulsed focused ultrasound while injecting ultrasound contrast agent containg microbubbles intravenously. The BBB opening was measured after the sonications by injecting MRI contrast agent IV and evaluating the local enhancement in the brain. Low ultrasound powers and pressure amplitudes were found to cause focal enhancement. Before sacrificing the animals trypan blue was also injected IV. After the sacrifice of the animals blue spots were found in the brain in the sonicated locations. This method may have potential for targeted delivery of macromolecules in the brain.

引用

页码：555 / 558

页数：4

共 50 条

[41] Non-invasive Neuromodulation Using Ultrasound
Vasan, Aditya
Friend, James
[J]. FASEB JOURNAL, 2020, 34
[42] ULTRASOUND - NON-INVASIVE IMAGING IN ABDOMEN
SIMONDS, BD
[J]. CONNECTICUT MEDICINE, 1978, 42 (01) : 10 - 14
[43] Investigation of non-invasive focused ultrasound efficacy on depressive-like behavior in hemiparkinsonian rats
Herlihy, Rachael A.
Alicandri, Francisco
Berger, Hudy
Rehman, Huda
Kao, Yifan
Akhtar, Kainat
Dybas, Elizabeth
Mahoney-Rafferty, Emily
Von Stein, Kassie
Kirby, Raven
Tawfik, Angela
Skumurski, Rachel
Feustel, Paul J.
Molho, Eric S.
Shin, Damian S.
[J]. EXPERIMENTAL BRAIN RESEARCH, 2024, 242 (02) : 321 - 336
[44] Transcranial MR-guided High Intensity Focused Ultrasound for Non-Invasive Functional Neurosurgery
Werner, Beat
Morel, Anne
Zadicario, Eyal
Jeanmonod, Daniel
Martin, Ernst
[J]. 9TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND, 2010, 1215 : 101 - +
[45] Investigation of non-invasive focused ultrasound efficacy on depressive-like behavior in hemiparkinsonian rats
Rachael A. Herlihy
Francisco Alicandri
Hudy Berger
Huda Rehman
Yifan Kao
Kainat Akhtar
Elizabeth Dybas
Emily Mahoney-Rafferty
Kassie Von Stein
Raven Kirby
Angela Tawfik
Rachel Skumurski
Paul J. Feustel
Eric S. Molho
Damian S. Shin
[J]. Experimental Brain Research, 2024, 242 : 321 - 336
[46] Focused Ultrasound as a Novel Non-Invasive Method for the Delivery of Gold Nanoparticles to Retinal Ganglion Cells
Park, Younghoon
Shin, Jaewoo
Park, Junwon
Kim, Seulbi
Park, Ji Hun
Kim, Jaeheung
Kim, Chang Seok
Chang, Jin Woo
Schuurmans, Carol
Aubert, Isabelle
Chang, Won Seok
Eom, Kyungsik
[J]. TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, 2024, 13 (05):
[47] In-vivo non-invasive motion tracking and correction in high intensity focused ultrasound therapy
Marquet, Fabrice
Pernot, Mathieu
Aubry, Jean-Francois
Tanter, Mickael
Montaldo, Gabriel
Fink, Mathias
[J]. 2006 28TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-15, 2006, : 4352 - +
[48] Efficacy and safety of non-invasive body tightening with high-intensity focused ultrasound (HIFU)
Ko, E. J.
Hong, J. Y.
Kwon, T. -R.
Choi, E. J.
Jang, Y. -J.
Choi, S. Y.
Yoo, K. H.
Kim, S. Y.
Kim, B. J.
[J]. SKIN RESEARCH AND TECHNOLOGY, 2017, 23 (04) : 558 - 562
[49] A review of high-intensity focused ultrasound as a novel and non-invasive interventional radiology technique
Ruihong Yao
Jihong Hu
Wei Zhao
Yongde Cheng
Chaofan Feng
[J]. Journal of Interventional Medicine, 2022, 5 (03) : 127 - 132
[50] In vivo exposure of the bladder using a non-invasive high intensity focused ultrasound toroidal transducer
Delattre, Victor
Cambronero, Sophie
Chen, Yao
ter Haar, Gail
Rivens, Ian
Polton, Gerry
Lafon, Cyril
Melodelima, David
[J]. ULTRASONICS, 2024, 138

← 1 2 3 4 5 →