Koshikamide A2, a cytotoxic linear undecapeptide isolated from a marine sponge of Theonella sp.

被引：13
|
作者：
Araki, T [1 ]
Matsunaga, S [1 ]
Fusetani, N [1 ]
机构：
[1] Univ Tokyo, Grad Sch Agr & Life Sci, Lab Aquat Nat Prod Chem, Bunkyo Ku, Tokyo 1138657, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2005年 / 69卷 / 07期
关键词：
cytotoxic metabolite; marine sponge; undecapeptide;
D O I：
10.1271/bbb.69.1318
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Koshikamide A(2) (2) was isolated as a cytotoxic metabolite from a marine sponge of Theonella sp. Its structure was elucidated to be a linear undecapeptide by spectroscopic and chemical methods, together with enzymatic conversion to known koshikamide A(1) (1). The new peptide moderately inhibited the growth of P388 murine leukemia cells.
引用
收藏
页码：1318 / 1322
页数：5
相关论文
共 50 条
  • [21] Callyspongiolide, a Cytotoxic Macrolide from the Marine Sponge Callyspongia sp.
    Cong-Dat Pham
    Hartmann, Rudolf
    Boehler, Philip
    Stork, Bjoern
    Wesselborg, Sebastian
    Lin, Wenhan
    Lai, Daowan
    Proksch, Peter
    ORGANIC LETTERS, 2014, 16 (01) : 266 - 269
  • [22] New cytotoxic metabolites from a marine sponge Homaxinella sp.
    Mansoor, TA
    Hong, J
    Lee, CO
    Sim, CJ
    Im, KS
    Lee, DS
    Jung, JH
    JOURNAL OF NATURAL PRODUCTS, 2004, 67 (04): : 721 - 724
  • [23] Cytotoxic Monocarbocyclic Sesterterpenoids from a Marine Sponge Luffariella sp.
    Su, Tzu-Rong
    Liao, Zuo-Jian
    Lu, Mei-Chin
    Wu, Yu-Jen
    Su, Jui-Hsin
    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 2015, 88 (01) : 176 - 182
  • [24] Pachastrissamine, a cytotoxic anhydrophytosphingosine from a marine sponge, Pachastrissa sp.
    Kuroda, I
    Musman, M
    Ohtani, II
    Ichiba, T
    Tanaka, J
    Gravalos, DG
    Higa, T
    JOURNAL OF NATURAL PRODUCTS, 2002, 65 (10): : 1505 - 1506
  • [25] Cytotoxic bisindole alkaloids from a marine sponge Spongosorites sp.
    Bao, BQ
    Sun, QS
    Yao, XS
    Hong, JK
    Lee, CO
    Sim, CJ
    Im, KS
    Jung, JH
    JOURNAL OF NATURAL PRODUCTS, 2005, 68 (05): : 711 - 715
  • [26] Cytotoxic sterol derivatives from a marine sponge Homaxinella sp.
    Mansoor, TA
    Hong, J
    Lee, CO
    Bae, SJ
    Im, KS
    Jung, JH
    JOURNAL OF NATURAL PRODUCTS, 2005, 68 (03): : 331 - 336
  • [27] Cytotoxic Polyacetylenes from a Formosan Marine Sponge Callyspongia sp.
    Chiu, Ching-Wen
    Su, Huey-Jen
    Lu, Mei-Chin
    Wang, Wei-Hsien
    Sheu, Jyh-Horng
    Su, Jui-Hsin
    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 2014, 87 (11) : 1231 - 1234
  • [28] Cytotoxic Scalarane Sesterterpenoids from a Marine Sponge Hippospongia sp.
    Fuh, Yuh-Ming
    Lu, Mei-Chin
    Lee, Chia-Hung
    Su, Jui-Hsin
    NATURAL PRODUCT COMMUNICATIONS, 2013, 8 (05) : 571 - 572
  • [29] Peloruside A:: A potent cytotoxic macrolide isolated from the New Zealand marine sponge Mycale sp.
    West, LM
    Northcote, PT
    Battershill, CN
    JOURNAL OF ORGANIC CHEMISTRY, 2000, 65 (02): : 445 - 449
  • [30] Lanesoic Acid: A Cytotoxic Zwitterion from Theonella sp.
    Rodriguez, Jaime
    Jimenez, Carlos
    Blanco, Maria
    Tarazona, Guillermo
    Fernandez, Rogelio
    Cuevas, Carmen
    ORGANIC LETTERS, 2016, 18 (22) : 5832 - 5835
12345