Ring chromosome 12 and severe oligospermia: a case report

Objective: To describe an unusual presentation of ring chromosome 12, which manifested as severe azoospermia, resulting in male infertility. Design: Case report. Setting: In vitro fertilization center at a tertiary care hospital. Patient(s): A 27-year-old man diagnosed with unexplained azoospermia and ring chromosome 12 abnormality during a workup for primary infertility. Intervention(s): In vitro fertilization with preimplantation genetic diagnosis. Main Outcome Measure(s): To confirm the importance of obtaining karyotypes in individuals with severe oligospermia. Result(s): Full-term pregnancy after IVF using donor sperm. Conclusion(s): Severe oligospermia and male infertility should be included in the spectrum of findings found in ring chromosome 12. (Fertil Steril (R) 2008; 90: 443. e13-e15. (C) 2008 by American Society for Reproductive Medicine.)