Synthesis and Biological Activity of Pyrazolidine-3,5-Dione Substituted Benzimidazole Derivatives

被引：0
|
作者：
Tiwari, Abhishek [1 ]
Tiwari, Varsha [1 ]
Venkataramana, C. H. S. [1 ]
Madhavan, V. [1 ]
机构：
[1] MS Ramaiah Coll Pharm, Dept Pharmaceut Chem, Bangalore 560054, Karnataka, India
来源：
ASIAN JOURNAL OF CHEMISTRY | 2011年 / 23卷 / 03期
关键词：
2-Chloromethyl benzimidazole; Pyrazolidine-3,5-dione; Antimicrobial activity; Antiinflammatory activity; 2-SUBSTITUTED BENZIMIDAZOLES;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Condensation of o-phenylene diamine with chloro acetic acid gave 2-chloromethyl benzimdazole, which undergoes halide replacement with phenylhydrazines to give the corresponding N,N'-disubstituted hydrazines. Later these compounds were treated with diethyl malonate in presence of acetic acid to get the pyrazolidine-3,5-dione substituted benzimidazole derivatives. The synthesized compounds were subjected to microbiological screening and in vitro antiinflammatory activity.
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页码：1179 / 1182
页数：4
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