Synthesis and Biological Activity of Pyrazolidine-3,5-Dione Substituted Benzimidazole Derivatives

被引：0

作者：

Tiwari, Abhishek ^{[1
]}

Tiwari, Varsha ^{[1
]}

Venkataramana, C. H. S. ^{[1
]}

Madhavan, V. ^{[1
]}

机构：

[1] MS Ramaiah Coll Pharm, Dept Pharmaceut Chem, Bangalore 560054, Karnataka, India

来源：

ASIAN JOURNAL OF CHEMISTRY | 2011年 / 23卷 / 03期

关键词：

2-Chloromethyl benzimidazole; Pyrazolidine-3,5-dione; Antimicrobial activity; Antiinflammatory activity; 2-SUBSTITUTED BENZIMIDAZOLES;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Condensation of o-phenylene diamine with chloro acetic acid gave 2-chloromethyl benzimdazole, which undergoes halide replacement with phenylhydrazines to give the corresponding N,N'-disubstituted hydrazines. Later these compounds were treated with diethyl malonate in presence of acetic acid to get the pyrazolidine-3,5-dione substituted benzimidazole derivatives. The synthesized compounds were subjected to microbiological screening and in vitro antiinflammatory activity.

引用

页码：1179 / 1182

页数：4

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