CONFORMATION SPECIFIC THERAPEUTIC VACCINES AGAINST PROTEIN MISFOLDING DISEASES

被引：0

作者：

Nicolau, Claude ^{[1
]}

机构：

[1] Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA

来源：

REVUE ROUMAINE DE CHIMIE | 2011年 / 56卷 / 04期

关键词：

Alzheimer Disease; conformation-sensitive antibodies; liposomes; memory recovery; transgenic mice; BETA-AMYLOID FIBRILS; ALZHEIMERS-DISEASE; TRANSGENIC MICE; IMMUNE-RESPONSE; P-GLYCOPROTEIN; MOUSE MODEL; PEPTIDE; IMMUNIZATION; CELLS; ACCUMULATION;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This is a brief review of our recent work concerning conformation-specific therapeutic vaccines, which have shown high efficacy against Alzheimer's Disease (AD), in animal models. The preparation of such vaccines, the determination of the antigen's conformation in the vaccine and the nature of the antibodies ellicited are discussed. The mechanism of the antibody action, in vitro and in vivo has been elucidated. The anti-amyloid vaccine is presently in a Phase I Clinical Trial on AD patients.

引用

页码：317 / +

页数：8

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