CONFORMATION SPECIFIC THERAPEUTIC VACCINES AGAINST PROTEIN MISFOLDING DISEASES

This is a brief review of our recent work concerning conformation-specific therapeutic vaccines, which have shown high efficacy against Alzheimer's Disease (AD), in animal models. The preparation of such vaccines, the determination of the antigen's conformation in the vaccine and the nature of the antibodies ellicited are discussed. The mechanism of the antibody action, in vitro and in vivo has been elucidated. The anti-amyloid vaccine is presently in a Phase I Clinical Trial on AD patients.