CDK4/6 Inhibitors: What Is the Best Cocktail?

被引：17
|
作者：
Malumbres, Marcos [1 ,2 ]
机构：
[1] Spanish Natl Canc Res Ctr CNIO, Cell Div, Madrid, Spain
[2] Spanish Natl Canc Res Ctr CNIO, Canc Grp, Madrid, Spain
来源：
CLINICAL CANCER RESEARCH | 2019年 / 25卷 / 01期
关键词：
D O I：
10.1158/1078-0432.CCR-18-2177
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
CDK4/6 inhibitors have shown great potential in the new armamentarium against cancer. However, their effect as single agents is limited, and the hopes are on new combinatory strategies. Recent data suggest that inhibiting mTOR may significantly cooperate with cell- cycle arrest in a variety of cancers.
引用
收藏
页码：6 / 8
页数：3
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