Molecular Regulation of Notch Signaling by Gremlin

被引：9

作者：

Marquez-Exposito, Laura ^{[1
,2
]}

Cantero-Navarro, Elena ^{[1
,2
]}

Rodrigues-Diez, Raul R. ^{[1
,2
]}

Orejudo, Macarena ^{[1
,2
]}

Tejera-Munoz, Antonio ^{[1
,2
]}

Tejedor, Lucia ^{[1
,2
]}

Rayego-Mateos, Sandra ^{[1
,3
]}

Randez-Carbayo, Javier ^{[1
,2
]}

Santos-Sanchez, Laura ^{[1
,2
]}

Mezzano, Sergio ^{[4
]}

Lavoz, Carolina ^{[4
]}

Ruiz-Ortega, Marta ^{[1
,2
]}

机构：

[1] Univ Autonoma Madrid, IIS Fdn Jimenez Diaz, Cellular & Mol Biol Renal & Vasc Pathol, Madrid, Spain

[2] Red Invest Renal REDINREN, Madrid, Spain

[3] Inst Recerca Biomed Lleida IRBLleida, Vasc & Renal Translat Res Grp, Lleida, Spain

[4] Univ Austral Chile, Sch Med, Div Nephrol, Valdivia, Chile

来源：

NOTCH SIGNALING IN EMBRYOLOGY AND CANCER: MOLECULAR BIOLOGY OF NOTCH SIGNALING, 2ND EDITION | 2020年 / 1227卷

关键词：

Gremlin; Notch; TGF-beta; BMP; VEGFR2; Renal damage; Fibrosis; Inflammation; BONE MORPHOGENETIC PROTEIN; NF-KAPPA-B; TGF-BETA; ANTAGONIST; EXPRESSION; PATHWAY; GROWTH; FIBROSIS; GENE; INFLAMMATION;

D O I：

10.1007/978-3-030-36422-9_6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gremlin is a member of the TGF-beta superfamily that can act as a BMP antagonist, and recently, has been described as a ligand of the vascular endothelial growth factor receptor 2 (VEGFR2). Gremlin shares properties with the Notch signaling pathway. Both participate in embryonic development and are reactivated in pathological conditions. Gremlin is emerging as a potential therapeutic target and biomarker of renal diseases. Here we review the role of the Gremlin-VEGFR2 axis in renal damage and downstream signaling mechanisms, such as Notch pathway.

引用

页码：81 / 94

页数：14

共 50 条

[21] Molecular Mechanisms of Notch Signaling Preface
Borggrefe, Tilman
Giaimo, Benedetto Daniele
MOLECULAR MECHANISMS OF NOTCH SIGNALING, 2018, 1066 : V - V
[22] Notch Signaling in Embryology and Cancer Molecular Biology of Notch Signaling Second Edition Preface
Reichrath, Joerg
Reichrath, Sandra
NOTCH SIGNALING IN EMBRYOLOGY AND CANCER: MOLECULAR BIOLOGY OF NOTCH SIGNALING, 2ND EDITION, 2020, 1227 : V - VI
[23] Regulation of acquired immune system by Notch signaling
Minato, Y
Yasutomo, K
INTERNATIONAL JOURNAL OF HEMATOLOGY, 2005, 82 (04) : 302 - 306
[24] Regulation of branching morphogenesis by hierarchical notch signaling
Napp, L. C.
JOURNAL OF VASCULAR RESEARCH, 2011, 48 : 338 - 338
[25] Regulation of Notch Signaling Through Intracellular Transport
Conner, Sean D.
INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 323, 2016, 323 : 107 - 127
[26] Regulation of Acquired Immune System by Notch Signaling
Yoshiaki Minato
Koji Yasutomo
International Journal of Hematology, 2005, 82 : 302 - 306
[27] Contextual Regulation of Skeletal Physiology by Notch Signaling
Daniel W. Youngstrom
Kurt D. Hankenson
Current Osteoporosis Reports, 2019, 17 : 217 - 225
[28] ALCOHOL REGULATION OF NOTCH SIGNALING IN VASCULAR CELLS
Hatch, E.
Morrow, D.
Cahill, P. A.
Redmond, E. M.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2013, 37 : 304A - 304A
[29] Notch Signaling in the Regulation of Hematopoietic Stem Cell
Lampreia F.P.
Carmelo J.G.
Anjos-Afonso F.
Current Stem Cell Reports, 2017, 3 (3) : 202 - 209
[30] Role of glycans and glycosyltransferases in the regulation of Notch signaling
Jafar-Nejad, Hamed
Leonardi, Jessica
Fernandez-Valdivia, Rodrigo
GLYCOBIOLOGY, 2010, 20 (08) : 931 - 949

← 1 2 3 4 5 →