The Role of Vitamin D in Cancer Prevention and Treatment

被引：51

作者：

Krishnan, Aruna V. ^{[2
]}

Trump, Donald L. ^{[3
]}

Johnson, Candace S. ^{[4
]}

Feldman, David ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Med, Div Endocrinol Gerontol & Metab, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Med, Div Endocrinol, Stanford, CA 94305 USA

[3] Roswell Pk Canc Inst, Dept Med, Buffalo, NY 14263 USA

[4] Roswell Pk Canc Inst, Dept Pharm & Therapeut, Buffalo, NY 14263 USA

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2012年 / 38卷 / 01期

关键词：

Vitamin D; Gene regulation; Antiproliferation; Antiinflammation; Cancer; Prevention; Treatment; NF-KAPPA-B; INDEPENDENT PROSTATE-CANCER; ENDOTHELIAL GROWTH-FACTOR; HIGH-DOSE CALCITRIOL; PHASE-II TRIAL; PROLIFERATIVE INFLAMMATORY ATROPHY; ANALOG SEOCALCITOL EB-1089; 1-ALPHA; 25-DIHYDROXYVITAMIN D-3; COLORECTAL-CANCER; BREAST-CANCER;

D O I：

10.1016/j.rdc.2012.03.014

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Calcitriol (1,25-dihydroxyvitamin D-3), the hormonally active form of vitamin D, exerts growth inhibitory and prodifferentiating effects on many malignant cells and retards tumor growth in animal models. Calcitriol is being evaluated as an anticancer agent in several human cancers. The mechanisms underlying the anticancer effects of calcitriol include inhibition of cell proliferation, stimulation of apoptosis, suppression of inflammation, and inhibition of tumor angiogenesis, invasion, and metastasis. This review discusses some of the molecular pathways mediating these anticancer actions of calcitriol and the preclinical data in cell culture and animal models. The clinical trials evaluating the use of calcitriol and its analogues in the treatment of patients with cancer are described. The reasons for the lack of impressive beneficial effects in clinical trials compared with the substantial efficacy seen in preclinical models are discussed.

引用

页码：161 / +

页数：19

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