Human papillomavirus status in young patients with head and neck squamous cell carcinoma
被引:31
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作者:
van Monsjou, H. S.
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机构:
NKI Antoni van Leeuwenhoek Hosp, Dept Head & Neck Oncol & Surg, Amsterdam, NetherlandsNKI Antoni van Leeuwenhoek Hosp, Dept Head & Neck Oncol & Surg, Amsterdam, Netherlands
van Monsjou, H. S.
[1
]
van Velthuysen, M. L. F.
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机构:
NKI Antoni van Leeuwenhoek Hosp, Dept Pathol, Amsterdam, NetherlandsNKI Antoni van Leeuwenhoek Hosp, Dept Head & Neck Oncol & Surg, Amsterdam, Netherlands
van Velthuysen, M. L. F.
[2
]
van den Brekel, M. W. M.
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机构:
NKI Antoni van Leeuwenhoek Hosp, Dept Head & Neck Oncol & Surg, Amsterdam, NetherlandsNKI Antoni van Leeuwenhoek Hosp, Dept Head & Neck Oncol & Surg, Amsterdam, Netherlands
van den Brekel, M. W. M.
[1
]
Jordanova, E. S.
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机构:
Leiden Univ, Med Ctr, Dept Pathol, NL-2300 RA Leiden, NetherlandsNKI Antoni van Leeuwenhoek Hosp, Dept Head & Neck Oncol & Surg, Amsterdam, Netherlands
Jordanova, E. S.
[3
]
Melief, C. J. M.
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机构:
Leiden Univ, Med Ctr, Dept Immunohaematol & Blood Transfus, NL-2300 RA Leiden, NetherlandsNKI Antoni van Leeuwenhoek Hosp, Dept Head & Neck Oncol & Surg, Amsterdam, Netherlands
Melief, C. J. M.
[4
]
Balm, A. J. M.
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机构:
NKI Antoni van Leeuwenhoek Hosp, Dept Head & Neck Oncol & Surg, Amsterdam, NetherlandsNKI Antoni van Leeuwenhoek Hosp, Dept Head & Neck Oncol & Surg, Amsterdam, Netherlands
Balm, A. J. M.
[1
]
机构:
[1] NKI Antoni van Leeuwenhoek Hosp, Dept Head & Neck Oncol & Surg, Amsterdam, Netherlands
[2] NKI Antoni van Leeuwenhoek Hosp, Dept Pathol, Amsterdam, Netherlands
[3] Leiden Univ, Med Ctr, Dept Pathol, NL-2300 RA Leiden, Netherlands
[4] Leiden Univ, Med Ctr, Dept Immunohaematol & Blood Transfus, NL-2300 RA Leiden, Netherlands
human papilloma virus;
young;
head and neck;
incidence;
p53;
p16;
ink4a;
squamous cell carcinoma;
ACTIVE HUMAN-PAPILLOMAVIRUS;
OROPHARYNGEAL CANCER;
CLINICAL-IMPLICATIONS;
ORAL-CANCER;
P53;
STATUS;
P16(INK4A);
HPV;
EXPRESSION;
TONSILLAR;
P16;
D O I:
10.1002/ijc.26195
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
The role of human papillomavirus (HPV) in head and neck squamous cell carcinoma (HNSCC) development has been recognized only in the last decade. Although younger patients develop HNSCC associated with HPV, the incidence in young patients has not been studied. Forty-five young HNSCC patients (<40 years) were tested for HPV and the expression of p16(ink4a) and p53 in tumor biopsies. The presence of HPV was correlated with the absence and presence of alcohol and tobacco exposure. Paraffin-embedded, archival biopsy materials from HNSCC of 45 patients younger than 40 years were analyzed. HPV subtypes were identified by PCR followed by genotyping. Expression of p16(ink4a) and p53 were determined by immunohistochemistry. Fourteen (31%) of the HNSCC specimens from 45 patients unequivocally exhibited HPV16 positivity. Sixty percentage of the oropharyngeal tumors and 5% of the oral cavity tumors were HPV16 positive. P16(ink4a) overexpression was detected in 93% of the HPV16-positive tumors. None of the HPV16 tumors showed p53 overexpression. There was no association of HPV positivity with (lack of) exposure to alcohol and smoking. HPV association was not exclusively detected in nonsmoking, nondrinking young HNSCC patients. The presence of p16(ink4a) accumulation and the absence of p53 overexpression are good surrogate markers for HPV-associated HNSCC.
机构:
Department of Head and Neck Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030Department of Head and Neck Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030
Li G.
Sturgis E.M.
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机构:
Department of Head and Neck Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030Department of Head and Neck Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030
机构:
King Edward Med Univ Lahore, Dept Oral & Maxillofacial Surg, Lahore, PakistanKing Edward Med Univ Lahore, Dept Oral & Maxillofacial Surg, Lahore, Pakistan
Warraich, R.
Udeabor, S. E.
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机构:
Hannover Med Sch, Dept Craniomaxillofacial Surg, Carl Neuberg Str 1, D-30625 Hannover, GermanyKing Edward Med Univ Lahore, Dept Oral & Maxillofacial Surg, Lahore, Pakistan
Udeabor, S. E.
Rana, M.
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机构:
Hannover Med Sch, Dept Craniomaxillofacial Surg, Carl Neuberg Str 1, D-30625 Hannover, GermanyKing Edward Med Univ Lahore, Dept Oral & Maxillofacial Surg, Lahore, Pakistan
Rana, M.
Eckardt, A. M.
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机构:
Hannover Med Sch, Dept Craniomaxillofacial Surg, Carl Neuberg Str 1, D-30625 Hannover, GermanyKing Edward Med Univ Lahore, Dept Oral & Maxillofacial Surg, Lahore, Pakistan
Eckardt, A. M.
Gellrich, N-C
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机构:
Hannover Med Sch, Dept Craniomaxillofacial Surg, Carl Neuberg Str 1, D-30625 Hannover, GermanyKing Edward Med Univ Lahore, Dept Oral & Maxillofacial Surg, Lahore, Pakistan
Gellrich, N-C
Rana, M.
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机构:
Hannover Med Sch, Dept Craniomaxillofacial Surg, Carl Neuberg Str 1, D-30625 Hannover, GermanyKing Edward Med Univ Lahore, Dept Oral & Maxillofacial Surg, Lahore, Pakistan
机构:
Univ Hong Kong, Prince Philip Dent Hosp, Fac Dent, Hong Kong, Hong Kong, Peoples R ChinaUniv Hong Kong, Prince Philip Dent Hosp, Fac Dent, Hong Kong, Hong Kong, Peoples R China
Gopinath, Divya
Menon, Rohit Kunnath
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Univ Hong Kong, Prince Philip Dent Hosp, Fac Dent, Hong Kong, Hong Kong, Peoples R ChinaUniv Hong Kong, Prince Philip Dent Hosp, Fac Dent, Hong Kong, Hong Kong, Peoples R China
机构:
Univ Southern Calif, Keck Sch Med, USC Tina & Rick Caruso Dept Otolaryngol Head & Ne, 1540 Alcazar St,Suite 204M, Los Angeles, CA 90033 USAUniv Southern Calif, Keck Sch Med, USC Tina & Rick Caruso Dept Otolaryngol Head & Ne, 1540 Alcazar St,Suite 204M, Los Angeles, CA 90033 USA
Low, Garren M.
Thylur, David S.
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机构:
Univ Southern Calif, Keck Sch Med, USC Tina & Rick Caruso Dept Otolaryngol Head & Ne, 1540 Alcazar St,Suite 204M, Los Angeles, CA 90033 USAUniv Southern Calif, Keck Sch Med, USC Tina & Rick Caruso Dept Otolaryngol Head & Ne, 1540 Alcazar St,Suite 204M, Los Angeles, CA 90033 USA
Thylur, David S.
Yamamoto, Vicky N.
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机构:
Univ Southern Calif, Keck Sch Med, USC Tina & Rick Caruso Dept Otolaryngol Head & Ne, 1540 Alcazar St,Suite 204M, Los Angeles, CA 90033 USAUniv Southern Calif, Keck Sch Med, USC Tina & Rick Caruso Dept Otolaryngol Head & Ne, 1540 Alcazar St,Suite 204M, Los Angeles, CA 90033 USA
Yamamoto, Vicky N.
Sinha, Uttam K.
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机构:
Univ Southern Calif, Keck Sch Med, USC Tina & Rick Caruso Dept Otolaryngol Head & Ne, 1540 Alcazar St,Suite 204M, Los Angeles, CA 90033 USAUniv Southern Calif, Keck Sch Med, USC Tina & Rick Caruso Dept Otolaryngol Head & Ne, 1540 Alcazar St,Suite 204M, Los Angeles, CA 90033 USA