Human papillomavirus status in young patients with head and neck squamous cell carcinoma

被引:31
|
作者
van Monsjou, H. S. [1 ]
van Velthuysen, M. L. F. [2 ]
van den Brekel, M. W. M. [1 ]
Jordanova, E. S. [3 ]
Melief, C. J. M. [4 ]
Balm, A. J. M. [1 ]
机构
[1] NKI Antoni van Leeuwenhoek Hosp, Dept Head & Neck Oncol & Surg, Amsterdam, Netherlands
[2] NKI Antoni van Leeuwenhoek Hosp, Dept Pathol, Amsterdam, Netherlands
[3] Leiden Univ, Med Ctr, Dept Pathol, NL-2300 RA Leiden, Netherlands
[4] Leiden Univ, Med Ctr, Dept Immunohaematol & Blood Transfus, NL-2300 RA Leiden, Netherlands
关键词
human papilloma virus; young; head and neck; incidence; p53; p16; ink4a; squamous cell carcinoma; ACTIVE HUMAN-PAPILLOMAVIRUS; OROPHARYNGEAL CANCER; CLINICAL-IMPLICATIONS; ORAL-CANCER; P53; STATUS; P16(INK4A); HPV; EXPRESSION; TONSILLAR; P16;
D O I
10.1002/ijc.26195
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The role of human papillomavirus (HPV) in head and neck squamous cell carcinoma (HNSCC) development has been recognized only in the last decade. Although younger patients develop HNSCC associated with HPV, the incidence in young patients has not been studied. Forty-five young HNSCC patients (<40 years) were tested for HPV and the expression of p16(ink4a) and p53 in tumor biopsies. The presence of HPV was correlated with the absence and presence of alcohol and tobacco exposure. Paraffin-embedded, archival biopsy materials from HNSCC of 45 patients younger than 40 years were analyzed. HPV subtypes were identified by PCR followed by genotyping. Expression of p16(ink4a) and p53 were determined by immunohistochemistry. Fourteen (31%) of the HNSCC specimens from 45 patients unequivocally exhibited HPV16 positivity. Sixty percentage of the oropharyngeal tumors and 5% of the oral cavity tumors were HPV16 positive. P16(ink4a) overexpression was detected in 93% of the HPV16-positive tumors. None of the HPV16 tumors showed p53 overexpression. There was no association of HPV positivity with (lack of) exposure to alcohol and smoking. HPV association was not exclusively detected in nonsmoking, nondrinking young HNSCC patients. The presence of p16(ink4a) accumulation and the absence of p53 overexpression are good surrogate markers for HPV-associated HNSCC.
引用
收藏
页码:1806 / 1812
页数:7
相关论文
共 50 条
  • [21] Human papillomavirus DNA and p16 expression in head and neck squamous cell carcinoma in young French patients
    Molimard, Chloe
    L'Huillier, Virginie
    Overs, Alexis
    Soret, Christine
    Algros, Marie-Paule
    Mougin, Christiane
    Guenat, David
    Mauvais, Olivier
    Pretet, Jean-Luc
    [J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2021, 49 (07)
  • [22] The role of human papillomavirus in squamous carcinoma of the head and neck
    Li G.
    Sturgis E.M.
    [J]. Current Oncology Reports, 2006, 8 (2) : 130 - 139
  • [23] Differentially expressed microRNA signatures based on human papillomavirus status in head and neck squamous cell carcinoma
    Howard, Jason D.
    Ratner, Elena
    Yarbrough, Wendell G.
    Slebos, Robbert J.
    Weidhaas, Joanne
    Chung, Christine H.
    [J]. CANCER RESEARCH, 2011, 71
  • [24] Characterization of Human Papillomavirus 16 Variants in Head-and-Neck Squamous Cell Carcinoma Patients
    Blakaj, D.
    Garg, M.
    Chen, Z.
    Smith, R.
    Prystowsky, M.
    Burk, R.
    Schlecht, N.
    Guha, C.
    Kalnicki, S.
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2012, 84 (03): : S711 - S712
  • [25] Role of human papillomavirus infection and other factors in patients with head and neck squamous cell carcinoma
    Iqbal, A.
    Warraich, R.
    Udeabor, S. E.
    Rana, M.
    Eckardt, A. M.
    Gellrich, N-C
    Rana, M.
    [J]. ORAL DISEASES, 2014, 20 (03) : 288 - 293
  • [26] Prevalence and physical status of human papillomavirus in squamous cell carcinomas of the head and neck
    Koskinen, WJ
    Chen, RW
    Leivo, I
    Mäkitie, A
    Bäck, L
    Kontio, R
    Suuronen, R
    Lindqvist, C
    Auvinen, E
    Molijn, A
    Quint, WG
    Vaheri, A
    Aaltonen, LM
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2003, 107 (03) : 401 - 406
  • [27] The significance of an algorithm for human papillomavirus detection in head and neck squamous cell carcinoma
    Gopinath, Divya
    Menon, Rohit Kunnath
    [J]. JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2018, 47 (05) : 540 - 540
  • [28] Human papillomavirus detection in head and neck squamous cell carcinoma in Turkey.
    Kemal, Yasemin
    Kemal, Ozgur
    Kefeli, Mehmet
    Bel, Ayse
    Sahin, Nilgun
    Atmaca, Sinan
    Koyuncu, Mehmet
    Yucel, Idris
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2017, 35
  • [29] Human papillomavirus-related head and neck squamous cell carcinoma variants
    El-Mofty, Samir K.
    [J]. SEMINARS IN DIAGNOSTIC PATHOLOGY, 2015, 32 (01) : 23 - 31
  • [30] The effect of human papillomavirus on DNA repair in head and neck squamous cell carcinoma
    Low, Garren M.
    Thylur, David S.
    Yamamoto, Vicky N.
    Sinha, Uttam K.
    [J]. ORAL ONCOLOGY, 2016, 61 : 27 - 30