Loss of DLC1 is an independent prognostic factor in patients with oral squamous cell carcinoma

被引：12

作者：

Tripathi, Satyendra Chandra ^{[3
]}

Kaur, Jatinder ^{[3
]}

Matta, Ajay ^{[1
,2
]}

Gao, Xin ^{[4
]}

Sun, Bin ^{[4
]}

Chauhan, Shyam Singh ^{[3
]}

Thakar, Alok ^{[5
]}

Shukla, Nootan Kumar ^{[6
]}

Duggal, Ritu ^{[7
]}

Choudhary, Ajoy Roy ^{[7
]}

DattaGupta, Siddhartha ^{[8
]}

Sharma, Mehar Chand ^{[8
]}

Ralhan, Ranju ^{[1
,2
,9
,10
,11
,12
,13
]}

Siu, K. W. Michael ^{[1
,2
]}

机构：

[1] York Univ, Dept Chem, Toronto, ON M3J 1P3, Canada

[2] York Univ, Ctr Res Mass Spectrometry, Toronto, ON M3J 1P3, Canada

[3] All India Inst Med Sci, Dept Biochem, New Delhi 110029, India

[4] York Univ, Dept Math & Stat, Toronto, ON M3J 1P3, Canada

[5] All India Inst Med Sci, Dept Otorhinolaryngol, New Delhi, India

[6] Dr BRA Inst Rotary Canc Hosp, All India Inst Med Sci, Dept Surg, New Delhi, India

[7] All India Inst Med Sci, Ctr Dent Educ & Res, New Delhi, India

[8] All India Inst Med Sci, Dept Pathol, New Delhi 110029, India

[9] Mt Sinai Hosp, Joseph & Mildred Sonshine Family Ctr Head & Neck, Toronto, ON M5G 1X5, Canada

[10] Mt Sinai Hosp, Dept Otolaryngol Head & Neck Surg, Toronto, ON M5G 1X5, Canada

[11] Mt Sinai Hosp, Alex & Simona Shnaider Lab Mol Oncol, Toronto, ON M5G 1X5, Canada

[12] Mt Sinai Hosp, Dept Pathol & Lab Med, Toronto, ON M5G 1X5, Canada

[13] Univ Toronto, Dept Otolaryngol Head & Neck Surg, Toronto, ON, Canada

来源：

MODERN PATHOLOGY | 2012年 / 25卷 / 01期

关键词：

DLC1; oral cancer; oral lesions; prognosis; oral squamous cell carcinoma; GTPASE-ACTIVATING PROTEIN; TUMOR-SUPPRESSOR GENE; MULTIDIMENSIONAL LIQUID-CHROMATOGRAPHY; NECK CANCER BIOMARKERS; LIVER-CANCER; EPITHELIAL DYSPLASIA; PROSTATE-CANCER; HEPATOCELLULAR-CARCINOMA; ABERRANT METHYLATION; EXPRESSION;

D O I：

10.1038/modpathol.2011.145

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Deleted in liver cancer (DLC1), a Rho GTPase-activating protein, was observed to be differentially expressed in oral squamous cell carcinoma in comparison with normal tissues using tissue proteomics. In the current study, we investigated the clinical significance of loss of DLC1 expression in different stages of development of oral squamous cell carcinoma to determine its potential as a biomarker for oral dysplasia and prognosis of oral squamous cell carcinoma. Immunohistochemical analysis of DLC1 expression was carried out in oral squamous cell carcinoma patients (n=214), dysplasia (n=51), hyperplastic squamous mucosa (n=45), and histologically normal oral tissues (n=80), and correlated with clinicopathological parameters and disease prognosis over 91 months for oral squamous cell carcinomas. Loss of DLC1 expression was observed in oral squamous cell carcinoma (64%), oral dysplasia (31%), hyperplastic squamous mucosa (22%), and normal mucosa (16%). Significant loss of DLC1 expression was observed in oral squamous cell carcinomas as compared with dysplasia (P<0.001, odds ratio=3.8, 95% CI=2.0-7.3), suggesting it may be an important event involved in cancer progression. Among oral squamous cell carcinomas, the loss of DLC1 expression was significantly associated with poor prognosis (P=0.021, hazards ratio (HR)=1.8, 95% CI=1.1-2.9). Multivariate analysis revealed loss of DLC1 (P=0.023, HR=2.1, 95% CI=1.2-3.9) and histopathological grade (P=0.015, HR=1.7, 95% CI=1.1-2.7) to be independent predictors for disease-free survival in oral squamous cell carcinoma patients in comparison with known prognostic factors, viz, tumor stage, nodal status, and overall stage. Loss of DLC1 expression emerged as an important biomarker for predicting patients diagnosed with oral dysplasia at high risk of transformation upon future validation in longitudinal studies. Loss of DLC1 expression is a poor prognostic marker for oral squamous cell carcinoma patients. Modern Pathology (2012) 25, 14-25; doi:10.1038/modpathol.2011.145; published online 14 October 2011

引用

下载

页码：14 / 25

页数：12

共 50 条

[41] Analysis of histological malignancy as a prognostic factor of oral squamous cell carcinoma
Iwai, Soichi
Nakazawa, Mitsuhiro
Suematsu, Motoo
Ozaki, Akiko
Yui, Shumpei
Yura, Yoshiaki
ANNALS OF ONCOLOGY, 2004, 15 : 143 - 143
[42] Aberrant expression of β- and γ-catenin is an independent prognostic marker in oral squamous cell carcinoma
Ueda, G
Sunakawa, H
Nakamori, K
Shinya, T
Tsuhako, W
Tamura, Y
Kosugi, T
Sato, N
Ogi, K
Hiratsuka, H
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2006, 35 (04) : 356 - 361
[43] FLOT-2 is an independent prognostic marker in oral squamous cell carcinoma
Wen, Qiuyuan
Alnemah, Mohannad Ma
Luo, Jiadi
Wang, Weiyuan
Chu, Shuzhou
Chen, Lingjiao
Li, Jiao
Xu, Lina
Li, Meirong
Zhou, Jianhua
Fan, Songqing
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2015, 8 (07): : 8236 - 8243
[44] GAP-independent functions of DLC1 in metastasis
David Barras
Christian Widmann
Cancer and Metastasis Reviews, 2014, 33 : 87 - 100
[45] Potential of lymph-node ratio as a prognostic factor for patients with oral squamous cell carcinoma
Tomo, Saygo
Ferreira Araujo, Winicius Arildo
de Castro, Tamara Fernandes
Conrado Neto, Sebastiao
Collado, Francisco Urbano
Biasoli, Eder Ricardo
Bernabe, Daniel Galera
Miyahara, Glauco Issamu
JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY, 2022, 123 (06) : E814 - E821
[46] Prognostic value of clinicopathological parameters and outcome in 484 patients with oral squamous cell carcinoma: microvascular invasion (V+) is an independent prognostic factor for OSCC
M. Grimm
Clinical and Translational Oncology, 2012, 14 : 870 - 880
[47] Prognostic value of clinicopathological parameters and outcome in 484 patients with oral squamous cell carcinoma: microvascular invasion (V plus ) is an independent prognostic factor for OSCC
Grimm, M.
CLINICAL & TRANSLATIONAL ONCOLOGY, 2012, 14 (11): : 870 - 880
[48] A20 as a novel prognostic factor for recurrence and patients' survival in oral squamous cell carcinoma
Spoerl, S.
Erber, R.
Gerken, M.
Fischer, R.
Taxis, J.
Meier, J. K.
Geppert, C., I
Hartmann, A.
Beckhove, P.
Mackensen, A.
Reichert, T.
Spanier, G.
Spoerl, S.
ONCOLOGY RESEARCH AND TREATMENT, 2021, 44 : 248 - 248
[49] GAP-independent functions of DLC1 in metastasis
Barras, David
Widmann, Christian
CANCER AND METASTASIS REVIEWS, 2014, 33 (01) : 87 - 100
[50] FGFR1 is an important prognostic factor in oral leukoplakia and tongue squamous cell carcinoma
Mariz, Bruno Augusto Linhares Almeida
de Sa, Raisa Sales
Araujo, Anna Luiza Damaceno
Fernandes, Carla Isabelly Rodrigues
Mariano, Fernanda Viviane
Santos-Silva, Alan Roger
Lopes, Marcio Ajudarte
Vargas, Pablo Agustin
de Almeida, Oslei Paes
Kowalski, Luiz Paulo
Jorge, Jacks
JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2023, 52 (02) : 119 - 126

← 1 2 3 4 5 →