Effect of endoscopic screening at 1-year intervals on the clinicopathologic characteristics and treatment of gastric cancer in South Korea

被引:23
|
作者
Yoon, Hyuk [2 ,3 ]
Kim, Nayoung [1 ,2 ,3 ]
Lee, Hye Seung [4 ]
Shin, Cheol Min [1 ]
Park, Young Soo [1 ,2 ,3 ]
Lee, Dong Ho [1 ,2 ,3 ]
Park, Do Joong [5 ]
Kim, Hyung Ho [5 ]
Jung, Hyun Chae [2 ,3 ]
机构
[1] Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Songnam 463707, Gyeonggi Do, South Korea
[2] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 151, South Korea
[3] Seoul Natl Univ, Coll Med, Liver Res Inst, Seoul, South Korea
[4] Seoul Natl Univ, Bundang Hosp, Dept Pathol, Songnam 463707, Gyeonggi Do, South Korea
[5] Seoul Natl Univ, Bundang Hosp, Dept Surg, Songnam 463707, Gyeonggi Do, South Korea
关键词
endoscopy; gastric cancer; screening; HELICOBACTER-PYLORI INFECTION; INTESTINAL METAPLASIA; ATROPHIC GASTRITIS; CHINESE POPULATION; SERUM PEPSINOGEN; X-RAY; RISK; ASSOCIATION; DIAGNOSIS;
D O I
10.1111/j.1440-1746.2011.07038.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background and Aim: The recommended interval of endoscopic screening for gastric cancer (GC) in a general population is 2 years in Korea. However, it has not been determined whether endoscopic screening with a shorter interval is beneficial, especially for high-risk groups. Methods: Atotal of 415 patients with GC were categorized according to whether they had (vigilant screening group) or not (non-vigilant screening group) undergone endoscopic screening within 1 year before being diagnosed with GC. Clinicopathologic GC characteristics of the two groups were compared. Next, the same analyses were conducted in subgroups of patients with high risk for GC including males, current smokers, first-degree relatives of GC; and patients with Helicobacter pylori infection, gastric atrophy, or intestinal metaplasia (IM). Results: The proportion of vigilant screening patients was 36.1%. Early gastric cancer (EGC) was more frequently observed in the vigilant screening group than the non-vigilant screening group (62.7% vs 49.4%, P = 0.009). In the high-risk factor analyses, EGC was more frequently detected among patients with severe IM in the vigilant screening group than the non-vigilant screening group (66.7% vs 35.5%, P = 0.047). In addition, more patients in the vigilant screening group had undergone endoscopic submucosal dissection (ESD; 26.7% vs 0%, P = 0.008) and had stage I (84.6% vs 41.7%, P = 0.012) than in the non-vigilant screening group. Conclusions: Endoscopic screening for GC at 1-year intervals would be beneficial for patients with severe IM in South Korea; this method could detect EGC for which the curative modality would be ESD.
引用
收藏
页码:928 / 934
页数:7
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