Microbial glycosylation of tanshinone IIA by Cunninghamella elegans AS 3.2028

被引：9

作者：

Liang, Wen-fei ^{[1
]}

Li, Zi-wei ^{[1
]}

Ji, Shuai ^{[1
]}

Wang, Qi ^{[1
]}

Qiao, Xue ^{[1
]}

Guo, De-an ^{[1
]}

Ye, Min ^{[1
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

来源：

RSC ADVANCES | 2015年 / 5卷 / 78期

基金：

中国国家自然科学基金;

关键词：

REDOX; NRF2;

D O I：

10.1039/c5ra09745b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tanshinone IIA (TIIA) is a natural product with significant anti-atherogenic activities. However, poor water-solubility and low bioavailability hinder its further exploitation as a drug candidate. In this study, microbial transformation of TIIA by Cunninghamella elegans AS 3.2028 was conducted to obtain two new glycosylated derivatives. Their structures were identified as hydroquinone TIIA 11-O-beta-D-glucopyranoside (1) and hydroquinone TIIA 12-O-beta-D-glucopyranoside (2) based on extensive NMR and MS spectral analyses. The solubility of 1 in 50% MeOH-H2O solution was approximately 50-fold that of TIIA, and 1 showed remarkably improved oral absorption in mice. Furthermore, 1 and 2 exhibited similar Nrf2 activation activity to TIIA.

引用

页码：63753 / 63756

页数：4

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