COVID-19 vaccinations: The unknowns, challenges, and hopes

被引：86

作者：

Mohamed, Kawthar ^{[1
,2
]}

Rzymski, Piotr ^{[3
,4
]}

Islam, Md Shahidul ^{[5
,6
]}

Makuku, Rangarirai ^{[1
,7
]}

Mushtaq, Ayesha ^{[8
,9
]}

Khan, Amjad ^{[10
,11
]}

Ivanovska, Mariya ^{[12
,13
]}

Makka, Sara A. ^{[14
,15
]}

Hashem, Fareeda ^{[1
,2
]}

Marquez, Leander ^{[16
,17
]}

Cseprekal, Orsolya ^{[18
,19
]}

Filgueiras, Igor Salerno ^{[20
,21
]}

Fonseca, Dennyson Leandro M. ^{[21
,22
]}

Mickael, Essouma ^{[23
,24
]}

Ling, Irene ^{[25
,26
]}

Arero, Amanuel Godana ^{[1
,27
]}

Cuschieri, Sarah ^{[28
,29
]}

Minakova, Kseniia ^{[30
,31
]}

Rodriguez-Roman, Eduardo ^{[32
,33
]}

Abarikwu, Sunny O. ^{[34
,35
]}

Faten, Attig-Bahar ^{[36
,37
]}

Grancini, Giulia ^{[38
,39
]}

Cabral-Marques, Otavio ^{[20
,21
,22
]}

Rezaei, Nima ^{[1
,40
,41
]}

机构：

[1] Univ Tehran Med Sci, Sch Med, Tehran, Iran

[2] Universal Sci Educ & Res Network USERN, Manama, Bahrain

[3] Poznan Univ Med Sci, Dept Environm Med, Poznan, Poland

[4] Universal Sci Educ & Res Network USERN, Poznan, Poland

[5] Univ Tehran Med Sci, Sch Adv Technol Med, Dept Tissue Engn & Appl Cell Sci, Tehran, Iran

[6] Universal Sci Educ & Res Network USERN, Dhaka, Bangladesh

[7] Universal Sci Educ & Res Network USERN, Harare, Zimbabwe

[8] Int Univ Kyrgyzstan, Int Higher Sch Med, Bishkek, Kyrgyzstan

[9] Universal Sci Educ & Res Network USERN, Bishkek, Kyrgyzstan

[10] Quaid i Azam Univ, Dept Pharm, Islamabad, Pakistan

[11] Universal Sci Educ & Res Network USERN, Islamabad, Pakistan

[12] Med Univ, Res Ctr, Dept Microbiol & Immunol, Plovdiv, Bulgaria

[13] Universal Sci Educ & Res Network USERN, Plovdiv, Bulgaria

[14] Lebanese Univ, Neurosci Res Ctr, Fac Med Sci, Beirut, Lebanon

[15] Universal Sci Educ & Res Network USERN, Beirut, Lebanon

[16] Univ Philippines Diliman, Coll Social Sci & Philosophy, Quezon City, Philippines

[17] Universal Sci Educ & Res Network USERN, Quezon City, Philippines

[18] Semmelweis Univ, Dept Transplantat & Surg, Budapest, Hungary

[19] Universal Sci Educ & Res Network USERN, Budapest, Hungary

[20] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Sao Paulo, Brazil

[21] Universal Sci Educ & Res Network USERN, Sao Paulo, Brazil

[22] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Analyses, Sao Paulo, Brazil

[23] Univ Libre Bruxelles, Erasme Hosp, Dept Rheumatol & Phys Med, Brussels, Belgium

[24] Universal Sci Educ & Res Network USERN, Yaounde, Cameroon

[25] Monash Univ Malasia, Sch Sci, Jalan Lagoon Selatan, Darul Ehsan, Selangor, Malaysia

[26] Universal Sci Educ & Res Network USERN, Darul Ehsan, Selangor, Malaysia

[27] Universal Sci Educ & Res Network USERN, Addis Ababa, Ethiopia

[28] Univ Malta, Fac Med & Surg, Msida, Malta

[29] Universal Sci Educ & Res Network USERN, Valletta, Malta

[30] Natl Tech Univ, Kharkiv Polytech Inst, Kharkiv, Ukraine

[31] Universal Sci Educ & Res Network USERN, Kiev, Ukraine

[32] Inst Venezolano Invest Cient, Ctr Microbiol & Cell Biol, Caracas, Venezuela

[33] Universal Sci Educ & Res Network USERN, Caracas, Venezuela

[34] Univ Port Harcourt, Dept Biochem, Choba, Nigeria

[35] Universal Sci Educ & Res Network USERN, Choba, Nigeria

[36] Univ Carthage, Tunisia Polytech Sch, Tunis, Tunisia

[37] Universal Sci Educ & Res Network USERN, Tunis, Tunisia

[38] Univ Pavia, Phys Chem Unit, Dept Chem, Pavia, Italy

[39] Universal Sci Educ & Res Network USERN, Pavia, Italy

[40] Univ Tehran Med Sci, Res Ctr Immunodeficiencies, Childrens Med Ctr, Tehran, Iran

[41] Universal Sci Educ & Res Network USERN, Tehran, Iran

来源：

JOURNAL OF MEDICAL VIROLOGY | 2022年 / 94卷 / 04期

基金：

巴西圣保罗研究基金会;

关键词：

COVID-19; vaccination; global assessment; global challenges; herd immunity; SARS-CoV-2; VACCINE; EFFICACY; IMMUNOGENICITY; REPLICATION; PREVENT; DISEASE; SPIKE;

D O I：

10.1002/jmv.27487

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The entire world has been suffering from the coronavirus disease 2019 (COVID-19) pandemic since March 11, 2020. More than a year later, the COVID-19 vaccination brought hope to control this viral pandemic. Here, we review the unknowns of the COVID-19 vaccination, such as its longevity, asymptomatic spread, long-term side effects, and its efficacy on immunocompromised patients. In addition, we discuss challenges associated with the COVID-19 vaccination, such as the global access and distribution of vaccine doses, adherence to hygiene guidelines after vaccination, the emergence of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, and vaccine resistance. Despite all these challenges and the fact that the end of the COVID-19 pandemic is still unclear, vaccines have brought great hope for the world, with several reports indicating a significant decline in the risk of COVID19-related infection and hospitalizations.

引用

页码：1336 / 1349

页数：14

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