Silencing of tripartite motif protein (TRIM) 5α mediated anti-HIV-1 activity by truncated mutant of TRIM5α

被引：15

作者：

Maegawa, Hikoichiro ^{[1
]}

Nakayama, Emi E. ^{[1
]}

Kuroishi, Ayumu ^{[1
]}

Shioda, Tatsuo ^{[1
]}

机构：

[1] Osaka Univ, Res Inst Microbial Dis, Dept Viral Infect, Suita, Osaka 5650871, Japan

来源：

JOURNAL OF VIROLOGICAL METHODS | 2008年 / 151卷 / 02期

关键词：

TRIM5; alpha; Sendai virus vector; SiRNA; human immunodeficiency virus type 1; knockdown; dominant-negative;

D O I：

10.1016/j.jviromet.2008.04.012

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Tripartite motif protein (TRIM) 5 alpha is a restriction factor of human immunodeficiency virus type I in Old World monkey cell. It was found that both naturally Occurring and artificial TRIM5 alpha variants lacking the SPRY domain Could silence TRIM5 alpha activity. Specifically, the artificial TRIM5 alpha mutant Could Suppress TRIM5 alpha activity of various primate species with even higher efficiency than Could small interfering RNAs. The findings indicate that TRIM5 alpha variants lacking the SPRY domain are useful for silencing TRIM5 alpha activity. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：249 / 256

页数：8

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