Unmasking the janus faces of autophagy in obesity-associated insulin resistance and cardiac dysfunction

被引：36

作者：

Xu, Xihui ^{[1
]}

Ren, Jun ^{[1
]}

机构：

[1] Univ Wyoming, Sch Pharm, Coll Hlth Sci, Ctr Cardiovasc Res & Alternat Med, Laramie, WY 82071 USA

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 2012年 / 39卷 / 02期

关键词：

autophagy; cardiovascular disease; heart; insulin resistance; obesity; HIGH-FAT-DIET; ACTIVATED PROTEIN-KINASE; BETA-CELL; CARDIOVASCULAR-DISEASE; HEMODYNAMIC STRESS; GLUCOSE-METABOLISM; LIPID-METABOLISM; SELF-DIGESTION; RISK-FACTOR; RAT-LIVER;

D O I：

10.1111/j.1440-1681.2011.05638.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Autophagy is an intracellular, lysosomal-dependent process involved in the turnover of long-lived proteins, damaged organelles and other subcellular structures. The autophagic process is known to play an essential role in the maintenance of cellular homeostasis. Results from recent studies also indicate an important role for the autophagic process in the pathogenesis of human diseases, including cancer, cardiovascular diseases, obesity, diabetes mellitus and ageing.

引用

页码：200 / 208

页数：9

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