Unmasking the janus faces of autophagy in obesity-associated insulin resistance and cardiac dysfunction

被引：36

作者：

Xu, Xihui ^{[1
]}

Ren, Jun ^{[1
]}

机构：

[1] Univ Wyoming, Sch Pharm, Coll Hlth Sci, Ctr Cardiovasc Res & Alternat Med, Laramie, WY 82071 USA

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 2012年 / 39卷 / 02期

关键词：

autophagy; cardiovascular disease; heart; insulin resistance; obesity; HIGH-FAT-DIET; ACTIVATED PROTEIN-KINASE; BETA-CELL; CARDIOVASCULAR-DISEASE; HEMODYNAMIC STRESS; GLUCOSE-METABOLISM; LIPID-METABOLISM; SELF-DIGESTION; RISK-FACTOR; RAT-LIVER;

D O I：

10.1111/j.1440-1681.2011.05638.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Autophagy is an intracellular, lysosomal-dependent process involved in the turnover of long-lived proteins, damaged organelles and other subcellular structures. The autophagic process is known to play an essential role in the maintenance of cellular homeostasis. Results from recent studies also indicate an important role for the autophagic process in the pathogenesis of human diseases, including cancer, cardiovascular diseases, obesity, diabetes mellitus and ageing.

引用

页码：200 / 208

页数：9

共 50 条

[1] Resistin and obesity-associated insulin resistance
Steppan, CM
Lazar, MA
TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2002, 13 (01): : 18 - 23
[2] S-Nitrosoglutathione Reductase Dysfunction Contributes to Obesity-Associated Hepatic Insulin Resistance via Regulating Autophagy
Qian, Qingwen
Zhang, Zeyuan
Orwig, Allyson
Chen, Songhai
Ding, Wen-Xing
Xu, Yanji
Kunz, Ryan C.
Lind, Nicholas R. L.
Stamler, Jonathan S.
Yang, Ling
DIABETES, 2018, 67 (02) : 193 - 207
[3] Microvascular dysfunction in obesity:: A potential mechanism in the pathogenesis of obesity-associated insulin resistance and hypertension
Jonk, Amy M.
Houben, Alfons J. H. M.
de Jongh, Renate T.
Serne, Erik H.
Schaper, Nicoloaas C.
Stehouwer, Coen D. A.
PHYSIOLOGY, 2007, 22 : 252 - 260
[4] Microvascular Dysfunction: A Potential Mechanism in the Pathogenesis of Obesity-associated Insulin Resistance and Hypertension
De Boer, Michiel P.
Meijer, Rick I.
Wijnstok, Nienke J.
Jonk, Amy M.
Houben, Alphons J.
Stehouwer, Coen D.
Smulders, Yvo M.
Eringa, Etto C.
Serne, Erik H.
MICROCIRCULATION, 2012, 19 (01) : 5 - 18
[5] INSULIN RESISTANCE, HYPERINSULINEMIA, AND OBESITY-ASSOCIATED HYPERTENSION
BRANDS, MW
HALL, JE
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 1992, 3 (05): : 1064 - 1077
[6] Obesity-Associated Insulin resistance in skeletal muscle
Nieto-Vazquez, Iria
Fernandez-Veledo, Sonia
Garcia-Guerra, Lucia
Vila-Bedmar, Rocio
Lorenzo, Margarita
ANALES DE LA REAL ACADEMIA NACIONAL DE FARMACIA, 2008, 74 (04): : 641 - 673
[7] Role of adipocytokines in obesity-associated insulin resistance
Zou, Chenhui
Shao, Jianhua
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2008, 19 (05): : 277 - 286
[8] Brain dysfunction in obesity-associated insulin resistance: Neuroprotection by taurine and N-acetylcysteine
Duarte, Joao
Garcia-Serrano, Alba
Vieira, Joao
JOURNAL OF NEUROCHEMISTRY, 2022, 162 : 78 - 79
[9] Normalization of obesity-associated insulin resistance through immunotherapy
Shawn Winer
Yin Chan
Geoffrey Paltser
Dorothy Truong
Hubert Tsui
Jasmine Bahrami
Ruslan Dorfman
Yongqian Wang
Julian Zielenski
Fabrizio Mastronardi
Yuko Maezawa
Daniel J Drucker
Edgar Engleman
Daniel Winer
H.-Michael Dosch
Nature Medicine, 2009, 15 : 921 - 929
[10] Contribution of TNF-α to obesity-associated insulin resistance
Lorenzo, Margarita
Fernandez-Veledo, Sonia
Vila-Bedmar, Rocio
Garcia-Guerra, Lucia
De Alvaro, Cristina
Nieto-Vazquez, Iria
ANALES DE LA REAL ACADEMIA NACIONAL DE FARMACIA, 2007, 73 (04): : 987 - 1008

← 1 2 3 4 5 →