Anesthesia: Synaptic power failure

被引：2

作者：

van Swinderen, Bruno ^{[1
]}

Kelz, Max B. ^{[2
]}

机构：

[1] Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia

[2] Univ Penn, Perelman Sch Med, Dept Anesthesiol & Crit Care, Philadelphia, PA 19104 USA

来源：

CURRENT BIOLOGY | 2022年 / 32卷 / 14期

关键词：

VOLATILE-ANESTHETICS; GENERAL-ANESTHESIA; SENSITIVITY; SLEEP;

D O I：

10.1016/j.cub.2022.06.043

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

One of the greatest unresolved mysteries in medicine relates to the molecular and neuronal mechanisms through which general anesthetics abolish perception. A new study in mice with mutations affecting mitochondrial complex 1 suggests that anesthetic-disruption of cellular energetics impairs endocytosis to alter synaptic function.

引用

页码：R781 / R783

页数：3

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