Design and Synthesis of a Bombesin Peptide-Conjugated Tripodal Phosphino Dithioether Ligand Topology for the Stabilization of the fac-[M(CO)3]+ Core (M=99 mTc or Re)

被引：11
|
作者：
Kannan, Raghuraman [1 ]
Pillarsetty, Nagavarakishore [1 ]
Gali, Hariprasad [1 ]
Hoffman, Timothy J. [2 ,4 ]
Barnes, Charles L. [3 ]
Jurisson, Silvia S. [3 ]
Smith, Charles J. [1 ,4 ]
Volkert, Wynn A. [1 ]
机构：
[1] Univ Missouri, Dept Radiol, Columbia, MO 65211 USA
[2] Univ Missouri, Dept Internal Med, Columbia, MO 65211 USA
[3] Univ Missouri, Dept Chem, Columbia, MO 65211 USA
[4] Univ Missouri, HS Truman Mem VA Hosp, Columbia, MO 65211 USA
来源：
INORGANIC CHEMISTRY | 2011年 / 50卷 / 13期
关键词：
IN-VIVO; TRICARBONYL COMPLEXES; TRIDENTATE LIGANDS; HUMAN PROSTATE; RECEPTORS; TECHNETIUM; CHEMISTRY; TC-99M; EXPRESSION; VITRO;
D O I：
10.1021/ic200491z
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A new tumor-seeking tridentate topology consisting of a phosphino dithioether ((HOCH2)(2)PCH2CH2S(CH2)(n)CH2SR; PS2) ligand framework for the production of kinetically inert and in vivo stable facial [Tc-99m(CO)(3)(PS2)](+) or [Re(CO)(3)(PS2)](+) is described. The X-ray crystal structure of fac-Re(CO)(3)(PS2)PF6 is reported. The bioconjugation strategies for incorporating bombesin (BBN) peptides on to the PS2 tripodal framework and, thereby, de novo designing of GRP receptor-seeking Tc(PS2-BBN)(CO)(3) are developed.
引用
收藏
页码：6210 / 6219
页数：10
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