Design and Synthesis of a Bombesin Peptide-Conjugated Tripodal Phosphino Dithioether Ligand Topology for the Stabilization of the fac-[M(CO)3]+ Core (M=99 mTc or Re)

被引：11

作者：

Kannan, Raghuraman ^{[1
]}

Pillarsetty, Nagavarakishore ^{[1
]}

Gali, Hariprasad ^{[1
]}

Hoffman, Timothy J. ^{[2
,4
]}

Barnes, Charles L. ^{[3
]}

Jurisson, Silvia S. ^{[3
]}

Smith, Charles J. ^{[1
,4
]}

Volkert, Wynn A. ^{[1
]}

机构：

[1] Univ Missouri, Dept Radiol, Columbia, MO 65211 USA

[2] Univ Missouri, Dept Internal Med, Columbia, MO 65211 USA

[3] Univ Missouri, Dept Chem, Columbia, MO 65211 USA

[4] Univ Missouri, HS Truman Mem VA Hosp, Columbia, MO 65211 USA

来源：

INORGANIC CHEMISTRY | 2011年 / 50卷 / 13期

关键词：

IN-VIVO; TRICARBONYL COMPLEXES; TRIDENTATE LIGANDS; HUMAN PROSTATE; RECEPTORS; TECHNETIUM; CHEMISTRY; TC-99M; EXPRESSION; VITRO;

D O I：

10.1021/ic200491z

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new tumor-seeking tridentate topology consisting of a phosphino dithioether ((HOCH2)(2)PCH2CH2S(CH2)(n)CH2SR; PS2) ligand framework for the production of kinetically inert and in vivo stable facial [Tc-99m(CO)(3)(PS2)](+) or [Re(CO)(3)(PS2)](+) is described. The X-ray crystal structure of fac-Re(CO)(3)(PS2)PF6 is reported. The bioconjugation strategies for incorporating bombesin (BBN) peptides on to the PS2 tripodal framework and, thereby, de novo designing of GRP receptor-seeking Tc(PS2-BBN)(CO)(3) are developed.

引用

页码：6210 / 6219

页数：10

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