FeCl3-catalyzed alkylation of indoles with 1,3-dicarbonyl compounds:: an expedient synthesis of 3-substituted indoles

被引：33

作者：

Yadav, J. S. ^{[1
]}

Reddy, B. V. Subba ^{[1
]}

Praneeth, K. ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 01期

关键词：

indoles; iron(III) reagents; 1,3-diketones; C-3; alkylation;

D O I：

10.1016/j.tetlet.2007.09.166

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Indoles undergo smooth alkylation at the 3-position with 1,3-dicarbonyl compounds in the presence of 20 mol % of FeCl3 under mild reaction conditions to produce a wide range of 3-substituted indoles in excellent yields and with high E-selectivity. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：199 / 202

页数：4

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