Asymmetric hydrogenation of ethyl pyruvate: Relationship between conversion and enantioselectivity

被引：56
|
作者：
Wang, J [1 ]
Sun, YK [1 ]
Leblond, C [1 ]
Landau, RN [1 ]
Blackmond, DG [1 ]
机构：
[1] MERCK & CO INC,RAHWAY,NJ 07065
来源：
JOURNAL OF CATALYSIS | 1996年 / 161卷 / 02期
关键词：
D O I：
10.1006/jcat.1996.0237
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The hydrogenation of ethyl pyruvate over cinchonidine-modified Pt exhibited intriguing transient behavior at the beginning of the reaction, and a period of rising rate and enantioselectivity was linked to conversion of substrate for a wide range of reaction temperatures and initial substrate concentrations. A ''reaction-driven equilibration'' of the surface environment for optimal enantioselective catalysis was proposed for these reactions carried out under conditions where moderate enantioselectivities are observed. (C) 1996 Academic Press, Inc.
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收藏
页码：752 / 758
页数：7
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