Mouse Yolk Sac Hematopoiesis

被引:46
|
作者
Yamane, Toshiyuki [1 ]
机构
[1] Mie Univ, Grad Sch Med, Dept Stem Cell & Dev Biol, Tsu, Mie, Japan
基金
日本学术振兴会;
关键词
yolk sac; blood cell development; embryonic hematopoiesis; fetal hematopoiesis; B-1 B cell; macrophage; STEM-CELLS; DEFINITIVE HEMATOPOIESIS; PRIMITIVE ERYTHROBLASTS; PROGENITORS; LINEAGE; ERYTHROPOIESIS; MACROPHAGES; DIFFERENTIATION; EXPRESSION; LACKING;
D O I
10.3389/fcell.2018.00080
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The yolk sac is the first observed site of hematopoiesis during mouse ontogeny. Primitive erythroid cells are the most well-recognized cell lineages produced from this tissue. In addition to primitive erythroid cells, several types of hematopoietic cells are present, including multipotent hematopoietic progenitors. Yolk sac-derived blood cells constitute a transient wave of embryonic and fetal hematopoiesis. However, recent studies have demonstrated that some macrophage and B cell lineages derived from the early yolk sac may persist to adulthood. This review discusses the cellular basis of mouse yolk sac hematopoiesis and its contributions to embryonic and adult hematopoietic systems.
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收藏
页数:8
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