Synthesis and Characterization of some Novel Quinoxaline-2, 3-Dione Derivatives: A Preliminary Investigation on their Activity Against a Human Epithelial Carcinoma Cell Line

被引：8
|
作者：
Jubie, Selvaraj [1 ]
Gayathri, Rajamanickam [1 ]
Srividya, Ammayappan Rajam [2 ]
Kalirajan, Rajagopal [1 ]
Prabitha, Prabakaran [1 ]
Sankar, Sundaram [1 ]
Elango, Kannan [1 ]
机构：
[1] Off Campus JSS Univ, JSS Coll Pharm, Dept Pharmaceut Chem, Mysore, Karnataka, India
[2] Off Campus JSS Univ, JSS Coll Pharm, Dept Pharmaceut Biotechnol, Mysore, Karnataka, India
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2011年 / 8卷 / 04期
关键词：
Benzimidazole; Cytotoxicity; Quinoxaline-2,3-dione; SRB method; Electrophilic substitution; Human epithelial carcinoma cell line;
D O I：
10.2174/157018011794839385
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Quinoxaline-2, 3-dione obtained from cyclocondensation reaction of o-phenylene diamine with oxalic acid, was reacted with chlorosulphonic acid under cold condition followed by a reaction with various benzimidazoles to give 2, 3-dioxo-1, 2, 3, 4-tetrahydroquinoxaline-6-sulphonyl benzimidazoles in satisfactory yield. Their structures were confirmed using H-1 NMR, IR and mass analysis. Cytotoxicity of these derivatives were evaluated by growth inhibition of HEp-2 cells in vitro. The preliminary bioassay indicated that these compounds showed moderate cytotoxicity.
引用
收藏
页码：317 / 320
页数：4
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