Rapid and Efficient Trimethylsilyl Protection of Hydroxyl Groups Catalyzed by Niobium(V) Chloride

被引：11
|
作者：
Hou, Jun-Tao [1 ]
Chen, Hong-Li [2 ]
Zhang, Zhan-Hui [1 ]
机构：
[1] Hebei Normal Univ, Coll Chem & Mat Sci, Shijiazhuang 050016, Peoples R China
[2] Hebei Chem & Pharmaceut Vocat Technol Coll, Shijiazhuang, Peoples R China
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2011年 / 186卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Hexamethyldisilazane; hydroxyl groups; niobium pentachloride; phenols; trimethylsilylation; SOLVENT-FREE; HEXAMETHYLDISILAZANE HMDS; HIGHLY EFFICIENT; REUSABLE CATALYST; O-SILYLATION; CHEMOSELECTIVE TRIMETHYLSILYLATION; FERRIC-CHLORIDE; ALCOHOLS; PHENOLS; MILD;
D O I：
10.1080/10426507.2010.482544
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
An efficient and convenient procedure for the trimethylsilylation of a wide variety of alcohols, including primary, benzylic, secondary, and phenols with hexamethyldisilazane, has been developed. The reactions were carried out at room temperature in the presence of a catalytic amount of niobium(V) chloride and afforded the corresponding trimethylsilyl ethers in high to excellent yields in short time. GRAPHICAL ABSTRACT[image omitted].
引用
收藏
页码：88 / 93
页数：6
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