Rapid and Efficient Trimethylsilyl Protection of Hydroxyl Groups Catalyzed by Niobium(V) Chloride

被引：11

作者：

Hou, Jun-Tao ^{[1
]}

Chen, Hong-Li ^{[2
]}

Zhang, Zhan-Hui ^{[1
]}

机构：

[1] Hebei Normal Univ, Coll Chem & Mat Sci, Shijiazhuang 050016, Peoples R China

[2] Hebei Chem & Pharmaceut Vocat Technol Coll, Shijiazhuang, Peoples R China

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2011年 / 186卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Hexamethyldisilazane; hydroxyl groups; niobium pentachloride; phenols; trimethylsilylation; SOLVENT-FREE; HEXAMETHYLDISILAZANE HMDS; HIGHLY EFFICIENT; REUSABLE CATALYST; O-SILYLATION; CHEMOSELECTIVE TRIMETHYLSILYLATION; FERRIC-CHLORIDE; ALCOHOLS; PHENOLS; MILD;

D O I：

10.1080/10426507.2010.482544

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An efficient and convenient procedure for the trimethylsilylation of a wide variety of alcohols, including primary, benzylic, secondary, and phenols with hexamethyldisilazane, has been developed. The reactions were carried out at room temperature in the presence of a catalytic amount of niobium(V) chloride and afforded the corresponding trimethylsilyl ethers in high to excellent yields in short time. GRAPHICAL ABSTRACT[image omitted].

引用

页码：88 / 93

页数：6

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