Thymosin beta 4 induces hair growth via stem cell migration and differentiation

被引：50
|
作者：
Philp, Deborah [1 ]
St-Surin, Sharleen [1 ]
Cha, Hee-Jae [1 ]
Moon, Hye-Sung [1 ]
Kleinman, Hynda K. [1 ]
Elkin, Michael [1 ]
机构：
[1] NIDCR, Cell Biol Sect, NIH, Bethesda, MD 20892 USA
来源：
THYMOSINS IN HEALTH AND DISEASE: FIRST INTERNATIONAL SYMPOSIUM | 2007年 / 1112卷
关键词：
cell migration; hair follicle growth; angiogenesis; wound healing; stem cells; cell survival; inflammation; gene expression; laminin-5; proteases; zyxin; endothelial cells; thymosin beta 4; keratinocytes; MMPs; TIMPs;
D O I：
10.1196/annals.1415.009
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Thymosin beta 4 is a small 43-amino-acid molecule that has multiple biological activities, including promotion of cell migration angiogenesis, cell survival, protease production, and wound healing. We have found that thymosin beta 4 promotes hair growth in various rat and mice models including a transgenic thymosin beta 4 overexpressing mouse. We have also determined the mechanism by which thymosin beta 4 acts to promote hair growth by examining its effects on follicle stem cell growth, migration, differentiation, and protease production.
引用
收藏
页码：95 / 103
页数：9
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