Identification of tyrosine residues of importance for survival signaling through the scaffolding protein Gab2 in both wild-type FLT3 and the FLT3-ITD

被引:0
|
作者
Masson, Kristina [1 ]
Liu, Tao [1 ]
Sun, Jianmin [1 ]
Ronnstrand, Lars [1 ]
机构
[1] Lund Univ, Dept Lab Med, Malmo, Sweden
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
1622
引用
收藏
页码:484A / 484A
页数:1
相关论文
共 50 条
  • [41] PP2A Activators Enhance Efficacy of FLT3 Inhibitors in FLT3-ITD Acute Myeloid Leukemia Cells through AKT Inactivation-Dependent Pim-1 and c-Myc Proteasomal Degradation
    Scarpa, Mario
    Singh, Prerna
    Kapoor, Shivani
    Lee, Jonelle K.
    Niyongere, Sandrine
    Narla, Goutham
    Perrotti, Danilo
    Baer, Maria R.
    BLOOD, 2019, 134
  • [42] Improved Posttransplant Outcomes in Recent Years for AML Patients with FLT3-ITD and Wild-type NPM1: A Report from the EBMT Acute Leukemia Working Party
    Bazarbachi, Ali
    Labopin, Myriam
    Gedde-Dahl, Tobias
    Remenyi, Peter
    Forcade, Edouard
    Kroeger, Nicolaus
    Socie, Gerard
    Craddock, Charles
    Bourhis, Jean Henri
    Versluis, Jurjen
    Yakoub-Agha, Ibrahim
    Salmenniemi, Urpu
    El-Cheikh, Jean
    Bug, Gesine
    Esteve, Jordi
    Nagler, Arnon
    Ciceri, Fabio
    Mohty, Mohamad
    CLINICAL CANCER RESEARCH, 2023, 29 (21) : 4441 - 4448
  • [43] A novel Axl and Mertk dual inhibitor ONO-7475: A new therapeutic agent for the treatment of FLT3-ITD and -wild-type acute myeloid leukemia (AML) overexpressing
    Tanaka, Kohei
    Li, Cuifang
    Hirosaki, Tomomi
    Kato, Hikaru
    Ishikawa, Yoshinori
    Oka, Miho
    Egawa, Hiroshi
    Kozaki, Ryohei
    Yoshizawa, Toshio
    CANCER RESEARCH, 2018, 78 (13)
  • [44] High-throughput Identification of FLT3 Wild-type and Mutant Kinase Substrate Preferences and Application to Design of Sensitive In Vitro Kinase Assay Substrates
    Perez, Minervo
    Blankenhorn, John
    Murray, Kevin J.
    Parker, Laurie L.
    MOLECULAR & CELLULAR PROTEOMICS, 2019, 18 (03) : 477 - 489
  • [45] CEBPA single mutation can be a possible favorable prognostic indicator in NPM1 and FLT3-ITD wild-type acute myeloid leukemia patients with intermediate cytogenetic risk
    Park, Sang Hyuk
    Chi, Hyun-Sook
    Cho, Young-Uk
    Jang, Seongsoo
    Park, Chan-Jeoung
    LEUKEMIA RESEARCH, 2013, 37 (11) : 1488 - 1494
  • [46] Potent graft-versus-leukaemia effect after reduced-intensity allogeneic stem-cell transplantation as post-remission therapy for intermediate-risk de-novo AML with FLT3-ITD genotype or wild-type (WT) NPM1 and CEBPA without FLT3-ITD
    Laboure, G.
    Vigouroux, S.
    Dulucq, S.
    Labopin, M.
    Lippert, E.
    Pigneux, A.
    Tabrizi, R.
    Leguay, T.
    Bouabdallah, K.
    Dilhuydy, M. S.
    Schmitt, A.
    Marit, G.
    Mahon, F. X.
    Milpied, N.
    BONE MARROW TRANSPLANTATION, 2012, 47 : S417 - S418
  • [47] LAM-003, a Novel Oral Heat Shock Protein 90 Inhibitor for Treatment of Acute Myeloid Leukemia, Including Wild-Type and FMS-like Tyrosine Kinase 3 (FLT3)-Mutant Disease
    Beeharry, Neil
    Landrette, Sean
    Grotzke, Jeff
    Gayle, Sophia
    Hernandez, Marylens
    Halene, Stephanie
    Young, Peter R.
    Miller, Langdon L.
    Xu, Tian
    Rothberg, Jonathan
    Lichenstein, Henri
    BLOOD, 2019, 134
  • [48] Phase IIB Trial of Oral Midostaurin (PKC412), the FMS-Like Tyrosine Kinase 3 Receptor (FLT3) and Multi-Targeted Kinase Inhibitor, in Patients With Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome With Either Wild-Type or Mutated FLT3
    Fischer, Thomas
    Stone, Richard M.
    DeAngelo, Daniel J.
    Galinsky, Ilene
    Estey, Elihu
    Lanza, Carlo
    Fox, Edward
    Ehninger, Gerhard
    Feldman, Eric J.
    Schiller, Gary J.
    Klimek, Virginia M.
    Nimer, Stephen D.
    Gilliland, D. Gary
    Dutreix, Catherine
    Huntsman-Labed, Alice
    Virkus, Jodi
    Giles, Francis J.
    JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (28) : 4339 - 4345
  • [49] QuANTUM-First Trial: FMS-like Tyrosine Kinase 3-Internal Tandem Duplication (FLT3-ITD)-Specific Measurable Residual Disease (MRD) Clearance Assessed Through Induction and Consolidation Is Associated with Improved Overall Survival (OS) in Newly Diagnosed (ND) FLT3-ITD+ AML Patients
    Perl, Alexander E.
    Erba, Harry P.
    Montesinos, Pau
    Vrhovac, Radovan
    Patkowska, Elzbieta
    Kim, Hee-Je
    Zak, Pavel
    Wang, Po-Nan
    Rohrbach, Jaime E. Connolly
    Chang, Ken C. N.
    Liu, Li
    Kamel, Yasser Mostafa
    Imadalou, Karima
    Lesegretain, Arnaud
    Cortes, Jorge
    Sekeres, Mikkael A.
    Dombret, Herve
    Amadori, Sergio
    Wang, Jianxiang
    Schlenk, Richard F.
    Levis, Mark J.
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2024, 24 : S298 - S298
  • [50] Concurrent Inhibition of Pim-1 and FLT3 Kinases in FLT3-ITD Acute Myeloid Leukemia Post-Translationally Downregulates the Anti-Apoptotic Protein Mcl-1 through Downregulation of the Mcl-1 Deubiquitinase USP9X
    Baldwin, Patrick R.
    Kapoor, Shivani
    Natarajan, Karthika
    Trotta, Rossana
    Tron, Adriana
    Huszar, Dennis
    Davila, Eduardo
    Perrotti, Danilo
    Baer, Maria R.
    BLOOD, 2016, 128 (22)