Interaction between platinum complexes and a methionine motif found in copper transport proteins

被引：83
|
作者：
Arnesano, Fabio [1 ]
Scintilla, Simone [1 ]
Natile, Giovanni [1 ]
机构：
[1] Univ Bari, Dipartimento Farmacochim, I-70125 Bari, Italy
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 47期
关键词：
antitumor agents; copper; methionine; NMR spectroscopy; platinum;
D O I：
10.1002/anie.200703271
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Going to the Mets: The uptake of Pt anticancer drugs also involves the Cu transporter Ctr1, which is located on the plasma membrane and contains functionally essential methionine-rich motifs. The methionine-rich peptide Mets7 reacts readily with PtII species. A striking difference between cis- and trans-[PtCl2(NH3)2] is that, upon reaction with Mets7, only the latter retains its N-donor ligands. Delivery of undegraded Pt drug to intracellular organelles by vesicle trafficking is hypothesized. (Figure Presented) © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：9062 / 9064
页数：3
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