Building and analysing an integrative model of HIV-1 RNA alternative splicing

被引：0
|
作者：
Bockmayr, A
Courtois, A
Eveillard, D
Vezain, M
机构：
[1] Univ Nancy, CNRS, INRIA, LORIA,UMR 7503, F-54506 Vandoeuvre Les Nancy, France
[2] CNRS, UHP, BP 239, UMR 7567,Lab Maturat ARN & Enzymol Mol, F-54506 Vandoeuvre Les Nancy, France
来源：
COMPUTATIONAL METHODS IN SYSTEMS BIOLOGY | 2005年 / 3082卷
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D O I：
暂无
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
We present a multi-site model describing the alternative use of the RNA splicing sites A3, A4, A5 and A7 in the human immunodeficiency virus HIV-1. Our goal is to integrate experimental data obtained on individual splicing sites into a global model of HIV-1 RNA alternative splicing. We give a qualitative validation of our model, and analyse the possible impact of variations of regulatory protein concentrations on virus multiplication.
引用
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页码：43 / 57
页数：15
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