Building and analysing an integrative model of HIV-1 RNA alternative splicing

被引：0

作者：

Bockmayr, A

Courtois, A

Eveillard, D

Vezain, M

机构：

[1] Univ Nancy, CNRS, INRIA, LORIA,UMR 7503, F-54506 Vandoeuvre Les Nancy, France

[2] CNRS, UHP, BP 239, UMR 7567,Lab Maturat ARN & Enzymol Mol, F-54506 Vandoeuvre Les Nancy, France

来源：

COMPUTATIONAL METHODS IN SYSTEMS BIOLOGY | 2005年 / 3082卷

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We present a multi-site model describing the alternative use of the RNA splicing sites A3, A4, A5 and A7 in the human immunodeficiency virus HIV-1. Our goal is to integrate experimental data obtained on individual splicing sites into a global model of HIV-1 RNA alternative splicing. We give a qualitative validation of our model, and analyse the possible impact of variations of regulatory protein concentrations on virus multiplication.

引用

页码：43 / 57

页数：15

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