Automated dissolution testing using the Zymark MultiDose

The Zymark MultiDose is a non-robotic dissolution workstation for the automation of USP Apparatus 2 (paddle) dissolution profiles. MultiDose can automate up to 8 standard 6-vessel dissolution tests without operator assistance. Analysis can be performed using on-line UV or offline by HPLC. MultiDose frees up analyst's time by automating crucial steps in dissolution testing such as; media sparging (using helium), preheating and dispensing into vessels; verification of vessel temperature; dropping of dosage forms (either in batch mode ''all at the same time'' or serial mode ''one at a time''); collection and filtration of sample aliquots at prescribed times; and cleaning of vessels at the end of the test. These steps can be repeated for up to 8 batches of tablets.