Phase 2B Efficacy and Safety of XEN1101, a Novel Potassium Channel Modulator, In Adults with Focal Epilepsy (X-TOLE)

被引：0
|
作者：
French, Jacqueline [1 ]
Porter, Roger [2 ]
Perucca, Emilio [3 ]
Brodie, Martin [4 ]
Rogawski, Michael A. [5 ]
Pimstone, Simon [6 ]
Aycardi, Ernesto [6 ]
Harden, Cynthia [6 ]
Xu, Yi [6 ]
Rosenblut, Constanza Luzon [6 ]
Kenney, Christopher [6 ]
Beatch, Greg [6 ]
机构：
[1] New York Univ, Comprehens Epilepsy Ctr, New York, NY USA
[2] Univ Penn, Philadelphia, PA USA
[3] Monash Univ, Melbourne, Vic, Australia
[4] Western Infirm & Associated Hosp, Univ Dept Med & Therapeut, Glasgow, Lanark, Scotland
[5] Univ Calif Davis, Sch Med, Sacramento, CA USA
[6] Xenon Pharmaceut, Vancouver, BC, Canada
来源：
NEUROTHERAPEUTICS | 2022年 / 19卷 / 04期
关键词：
D O I：
暂无
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
29
引用
收藏
页码：1427 / 1427
页数：1
相关论文
共 50 条
  • [21] Selective Orexin Receptor Antagonists as Novel Augmentation Treatments for Major Depressive Disorder: Evidence for Safety and Efficacy From a Phase 2B Study of Seltorexant
    Jha, Manish Kumar
    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2022, 25 (01): : 85 - 88
  • [22] Efficacy and safety of islatravir in combination with doravirine through 144 weeks for treatment-naive adults with HIV-1 infection in a phase 2b trial
    Molina, J. -M.
    Yazdanpanah, Y.
    Saud, A. Afani
    Bettacchi, C.
    Anania, C. Chahin
    Klopfer, S. Olsen
    Grandhi, A.
    Eves, K.
    Hepler, D.
    Lahoulou, R.
    Correll, T.
    HIV MEDICINE, 2021, 22 : 6 - 7
  • [23] Efficacy and Safety of Lebrikizumab, a High-Affinity Interleukin 13 Inhibitor, in Adults With Moderate to Severe Atopic Dermatitis A Phase 2b Randomized Clinical Trial
    Guttman-Yassky, Emma
    Blauvelt, Andrew
    Eichenfield, Lawrence F.
    Paller, Amy S.
    Armstrong, April W.
    Drew, Janice
    Gopalan, Ramanan
    Simpson, Eric L.
    JAMA DERMATOLOGY, 2020, 156 (04) : 411 - 420
  • [24] Respiratory safety signal with oliceridine (TRV130), a novel μ receptor G protein pathway selective modulator (μ-GPS), vs morphine: a safety analysis of a Phase 2b randomized clinical trial
    Singla, N.
    Minkowitz, H.
    Soergel, D.
    Burt, D.
    Skobieranda, F.
    JOURNAL OF PAIN, 2016, 17 (04): : S82 - S82
  • [25] EFFICACY AND SAFETY FROM A PHASE 2B TRIAL OF SM04690, A NOVEL, INTRA-ARTICULAR WNT PATHWAY INHIBITOR FOR THE TREATMENT OF OSTEOARTHRITIS OF THE KNEE
    Yazici, Yusuf
    McAlindon, Timothy
    Gibofsky, Allan
    Lane, Nancy
    Latterman, Christian
    Skrepnik, Nebojsa
    Swearingen, Chris
    DiFrancesco, Anita
    Tambiah, Jeyanesh
    Hochberg, Marc
    Grifman, Mirta
    JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, 2019, 25 : S12 - S12
  • [26] EFFICACY AND SAFETY FROM A PHASE 2B TRIAL OF SM04690, A NOVEL, INTRA-ARTICULAR, WNT PATHWAY INHIBITOR FOR THE TREATMENT OF OSTEOARTHRITIS OF THE KNEE
    Yazici, Y.
    McAlindon, T. E.
    Gibofsky, A.
    Lane, N. E.
    Latterman, C.
    Skrepnik, N.
    Swearingen, C. J.
    DiFrancesco, A.
    Tambiah, J. R.
    Hochberg, M. C.
    OSTEOARTHRITIS AND CARTILAGE, 2019, 27 : S503 - S503
  • [27] EFFICACY AND SAFETY FROM A PHASE 2B TRIAL OF SM04690, A NOVEL INTRA-ARTICULAR WNT PATHWAY INHIBITOR FOR THE TREATMENT OF OSTEOARTHRITIS OF THE KNEE
    Yazici, Yusuf
    Mcalindon, Timothy
    Gibofsky, Allan
    Lane, Nancy
    Lattermann, Christian
    Skrepnik, Nebojsa
    Swearingen, Christopher
    Difrancesco, Anita
    Tambiah, Jeyanesh
    Hochberg, Marc
    ANNALS OF THE RHEUMATIC DISEASES, 2019, 78 : 519 - 519
  • [28] Efficacy and safety of emodepside compared with albendazole in adolescents and adults with hookworm infection in Pemba Island, Tanzania: a double-blind, superiority, phase 2b, randomised controlled trial
    Taylor, Lyndsay
    Ahmada, Ahmada Ali
    Ali, Msanif Said
    Ali, Said Mohammed
    Hattendorf, Jan
    Mohammed, Ibrahim Said
    Keiser, Jennifer
    LANCET, 2024, 404 (10453): : 683 - 691
  • [29] Efficacy, safety, and immunogenicity of the Shigella sonnei 1790GAHB GMMA candidate vaccine: Results from a phase 2b randomized, placebo-controlled challenge study in adults
    Frenck Jr, Robert W.
    Conti, Valentino
    Ferruzzi, Pietro
    Ndiaye, Augustin G. W.
    Parker, Susan
    McNeal, Monica Malone
    Dickey, Michelle
    Granada, Juan Paolo
    Cilio, Giulia Luna
    De Ryck, Iris
    Necchi, Francesca
    Suvarnapunya, Akamol E.
    Rossi, Omar
    Acquaviva, Alessandra
    Chandrasekaran, Lakshmi
    Clarkson, Kristen A.
    Auerbach, Joachim
    Marchetti, Elisa
    Kaminski, Robert W.
    Micoli, Francesca
    Rappuoli, Rino
    Saul, Allan
    Martin, Laura B.
    Podda, Audino
    ECLINICALMEDICINE, 2021, 39
  • [30] Efficacy and Safety of Danirixin (GSK1325756) Co-administered With Standard-of-Care Antiviral (Oseltamivir): A Phase 2b, Global, Randomized Study of Adults Hospitalized With Influenza
    Madan, Anuradha
    Chen, Shuguang
    Yates, Phillip
    Washburn, Michael L.
    Roberts, Grace
    Peat, Andrew J.
    Tao, Yu
    Parry, Michael F.
    Barnum, Otis
    McClain, Micah T.
    Roy-Ghanta, Sumita
    OPEN FORUM INFECTIOUS DISEASES, 2019, 6 (04):
12345