A "turn-on'' fluorescent probe for the detection of Cu2+ in living cells based on a signaling mechanism of N=N isomerization

被引：27

作者：

Cao, Shuo ^{[1
]}

Jin, Qiaoying ^{[1
,2
,3
]}

Geng, Lin ^{[1
]}

Mu, Lingyun ^{[1
]}

Dong, Shouliang ^{[1
,4
]}

机构：

[1] Lanzhou Univ, Sch Life Sci, Inst Biochem & Mol Biol, 222 Tianshui South Rd, Lanzhou 730000, Peoples R China

[2] Lanzhou Univ, Hosp 2, Med Genet Lab, Lanzhou 730030, Peoples R China

[3] Key Lab Digest Syst Tumors Gansu Prov, Lanzhou 730030, Peoples R China

[4] Key Lab Preclin Study New Drugs Gansu Prov, 222 Tianshui South Rd, Lanzhou 730000, Peoples R China

来源：

NEW JOURNAL OF CHEMISTRY | 2016年 / 40卷 / 07期

关键词：

TRANSITION-METAL IONS; SELECTIVE FLUORESCENT; C=N ISOMERIZATION; AQUEOUS-SOLUTION; SCHIFF-BASE; CHEMOSENSOR; COPPER; CHEMODOSIMETER; ZN2+; SENSOR;

D O I：

10.1039/c5nj03649f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel fluorescent probe A based on coumarin associated with a N=N double bond was conveniently designed and synthesized for Cu2+, and both rapid colorimetric and fluorescence turn-on detection can be achieved, showing a visible color change from pink to yellow and a significant fluorescence enhancement, respectively. The probe exhibits high selectivity toward Cu2+ over other metal ions and excellent sensitivity with a detection limit of 20 nM, and it can be monitored in a wide range of pH (3-10) in aqueous systems. Besides, the probe has been applied in living cells.

引用

页码：6264 / 6269

页数：6

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