A "turn-on'' fluorescent probe for the detection of Cu2+ in living cells based on a signaling mechanism of N=N isomerization

被引：27
|
作者：
Cao, Shuo [1 ]
Jin, Qiaoying [1 ,2 ,3 ]
Geng, Lin [1 ]
Mu, Lingyun [1 ]
Dong, Shouliang [1 ,4 ]
机构：
[1] Lanzhou Univ, Sch Life Sci, Inst Biochem & Mol Biol, 222 Tianshui South Rd, Lanzhou 730000, Peoples R China
[2] Lanzhou Univ, Hosp 2, Med Genet Lab, Lanzhou 730030, Peoples R China
[3] Key Lab Digest Syst Tumors Gansu Prov, Lanzhou 730030, Peoples R China
[4] Key Lab Preclin Study New Drugs Gansu Prov, 222 Tianshui South Rd, Lanzhou 730000, Peoples R China
来源：
NEW JOURNAL OF CHEMISTRY | 2016年 / 40卷 / 07期
关键词：
TRANSITION-METAL IONS; SELECTIVE FLUORESCENT; C=N ISOMERIZATION; AQUEOUS-SOLUTION; SCHIFF-BASE; CHEMOSENSOR; COPPER; CHEMODOSIMETER; ZN2+; SENSOR;
D O I：
10.1039/c5nj03649f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel fluorescent probe A based on coumarin associated with a N=N double bond was conveniently designed and synthesized for Cu2+, and both rapid colorimetric and fluorescence turn-on detection can be achieved, showing a visible color change from pink to yellow and a significant fluorescence enhancement, respectively. The probe exhibits high selectivity toward Cu2+ over other metal ions and excellent sensitivity with a detection limit of 20 nM, and it can be monitored in a wide range of pH (3-10) in aqueous systems. Besides, the probe has been applied in living cells.
引用
收藏
页码：6264 / 6269
页数：6
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