Porcine and human relaxin bioactivity - Bioactivities of porcine relaxin and human relaxin do not differ in mice and rats

被引：2
|
作者：
Zhao, SP
Lee, HY
Sherwood, OD
机构：
[1] Univ Illinois, Dept Mol & Integrat Physiol, Urbana, IL 61801 USA
[2] Univ Illinois, Coll Med, Urbana, IL 61801 USA
来源：
RELAXIN AND RELATED PEPTIDES: FOURTH INTERNATIONAL CONFERENCE | 2005年 / 1041卷
关键词：
porcine relaxin; recombinant human relaxin; mouse interpubic ligament; rat cervix;
D O I：
10.1196/annals.1282.018
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This study compares the bioactivity of porcine relaxin-1 to that of recombinant human relaxin-2 in mice and rats. The effects of the two hormone preparations on elongation of the mouse interpubic ligament and both the wet weight and the extensibility of the rat cervix were compared. No difference in bioactivity was detected between porcine relaxin-1 and recombinant human relaxin-2 in either rodent. Therefore, decisions concerning which of the two available forms of relaxin to employ for in vivo experimentation in mice and rats can be made without concerns about relative bioactivity.
引用
收藏
页码：126 / 131
页数：6
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