Anti-inflammatory steroids from the rhizomes of Dioscorea septemloba Thunb

被引：34

作者：

Zhang, Yi ^{[1
]}

Yu, Hai-Yang ^{[1
]}

Chao, Li-Ping ^{[2
]}

Qu, Lu ^{[1
]}

Ruan, Jing-Ya ^{[2
]}

Liu, Yan-Xia ^{[1
]}

Dong, Yong-Zhe ^{[2
]}

Han, Li-Feng ^{[2
]}

Wang, Tao ^{[1
]}

机构：

[1] Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, 312 Anshanxi Rd, Tianjin 300193, Peoples R China

[2] Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, Tianjin Key Lab TCM Chem & Anal, 312 Anshan Rd, Tianjin 300193, Peoples R China

来源：

STEROIDS | 2016年 / 112卷

关键词：

Dioscorea septemloba Thunb; Steroids; Anti-inflammatory activity; GLYCOSIDES; SAPONINS;

D O I：

10.1016/j.steroids.2016.05.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Seven new steroid glycosides, dioscorosides A(1) (1), A(2) (2), B-1 (3), B-2 (4), C-1 (5), C-2 (6), and D (7), together with 22 known ones (8-29) were isolated from the rhizomes of Dioscorea septemloba, their structures were elucidated by chemical and spectroscopic methods. All isolates were evaluated for in vitro anti-inflammatory potential using LPS-stimulated RAW 264.7 murine macrophages. Among, them,, spirostane glycosides 18 and 21-24 exhibited significant inhibition of nitrite production. Moreover, the structure activity relationship was summarized. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：95 / 102

页数：8

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