Effects of Electrospinning Parameter Adjustment on the Mechanical Behavior of Poly-ε-caprolactone Vascular Scaffolds

被引:10
|
作者
Dokuchaeva, Anna A. [1 ]
Timchenko, Tatyana P. [1 ]
Karpova, Elena V. [2 ]
Vladimirov, Sergei V. [1 ]
Soynov, Ilya A. [1 ]
Zhuravleva, Irina Y. [1 ]
机构
[1] E Meshalkin Natl Med Res Ctr RF, Inst Expt Biol & Med, Minist Hlth, 15 Rechkunovskaya St, Novosibirsk 630055, Russia
[2] RAS, NN Vorozhtsov Novosibirsk Inst Organ Chem, SB, Grp Opt Spectrometry,Ctr Spectral Invest, 9 Lavrentiev Ave, Novosibirsk 630090, Russia
基金
俄罗斯科学基金会;
关键词
electrospinning; mechanical testing; polycaprolactone; tissue engineering; vascular scaffolds; NANOFIBER DIAMETER; MORPHOLOGY; GRAFT;
D O I
10.3390/polym14020349
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Electrospinning is a perspective method widely suggested for use in bioengineering applications, but the variability in currently available data and equipment necessitates additional research to ascertain the desirable methodology. In this study, we aimed to describe the effects of electrospinning technique alterations on the structural and mechanical properties of (1,7)-polyoxepan-2-one (poly-epsilon-caprolactone, PCL) scaffolds, such as circumferential and longitudinal stress/strain curves, in comparison with corresponding properties of fresh rat aorta samples. Scaffolds manufactured under different electrospinning modes were analyzed and evaluated using scanning electronic microscopy as well as uniaxial longitudinal and circumferential tensile tests. Fiber diameter was shown to be the most crucial characteristic of the scaffold, correlating with its mechanical properties.
引用
收藏
页数:16
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