Stereoselective Synthesis of Trisubstituted Epoxides Marks the Route to Chiral Building Blocks with Quaternary Centers

被引：4

作者：

Garcia-Castro, Miguel ^{[1
]}

Annamalai, Murali ^{[1
]}

Golz, Christopher ^{[2
]}

Strohmann, Carsten ^{[2
]}

Kumar, Kamal ^{[1
]}

机构：

[1] Max Planck Inst Mol Physiol, Abt Chem Biol, Otto Hahn Str 11, D-44227 Dortmund, Germany

[2] Tech Univ Dortmund, Fak Chem & Chem Biol, Otto Hahn Str 6, D-44221 Dortmund, Germany

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 2017卷 / 37期

关键词：

Asymmetric synthesis; Epoxidation; Sulfur; Ylides; Ketones; Amino alcohols; CATALYTIC ASYMMETRIC EPOXIDATION; HIGHLY ENANTIOSELECTIVE EPOXIDATION; GLYCIDIC AMIDES; SULFUR YLIDES; SULFONIUM SALTS; AMINO-ACIDS; IN-SITU; ALDEHYDES; KETONES; MECHANISM;

D O I：

10.1002/ejoc.201701148

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile access to enantiomerically pure derivatives of alpha-hydroxy-beta-amino acids bearing a quaternary center and trifluoromethylated tertiary alcohols, which represent highly important building blocks for therapeutically relevant small molecules, has been efficiently achieved by developing an asymmetric epoxidation of alpha-activated ketones by employing chiral sulfur ylides.

引用

页码：5660 / 5665

页数：6

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