Extensive Shared Chemosensitivity between Malaria and Babesiosis Blood-Stage Parasites

被引：19

作者：

Paul, Aditya S. ^{[1
]}

Moreira, Cristina K. ^{[1
]}

Elsworth, Brendan ^{[1
]}

Allred, David R. ^{[2
,3
]}

Duraisingh, Manoj T. ^{[1
]}

机构：

[1] Harvard TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

[2] Univ Florida, Dept Infect Dis & Pathol, Gainesville, FL USA

[3] Univ Florida, Emerging Pathogens Inst, Gainesville, FL USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2016年 / 60卷 / 08期

关键词：

BOX; IDENTIFICATION; ANTIMALARIALS; INFECTIONS; MEDICINES; DIVERGENS; REVEALS; GENOME; MODEL; BOVIS;

D O I：

10.1128/AAC.00928-16

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The apicomplexan parasites that cause malaria and babesiosis invade and proliferate within erythrocytes. To assess the potential for common antiparasitic treatments, we measured the sensitivities of multiple species of Plasmodium and Babesia parasites to the chemically diverse collection of antimalarial compounds in the Malaria Box library. We observed that these parasites share sensitivities to a large fraction of the same inhibitors and we identified compounds with strong babesiacidal activity.

引用

页码：5059 / 5063

页数：5

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