In vitro and in vivo effects of oxidative damage to deoxyguanosine

被引：40
|
作者：
Greenberg, MM [1 ]
机构：
[1] Johns Hopkins Univ, Dept Chem, Baltimore, MD 21218 USA
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2004年 / 32卷
关键词：
base-excision repair; deoxyguanosine (dG); 7,8-dihydno-8-hydroxy-2 '-deoxyguanosine; (OxodG); DNA lesion; oxidative damage; secondary oxidation product;
D O I：
10.1042/BST0320046
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Biochemical, biophysical and biological studies of oligonuclecitides containing lesions at defined sites provide a molecular basis for the effects of DNA lesions. dG (deoxyguanosine) is the most easily oxidized of the four native nuclecitides. The chemical reactivity of dG correlates with compilations of mutations, which reveal that a significant fraction of transitions or transversions involve dG. OxodG (7,8-dihydro-8-hydroxy2'-deoxyguanosine) is widely recognized as an important lesion derived from the oxidation of dG, and significant effort has been expended in studies of its effects on DNA structure and function. Recently, the properties of other lesions derived from dG and/or the oxidation of OxodG have been uncovered. Studies on these lesions reveal that they too are biologically significant.
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收藏
页码：46 / 50
页数：5
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